CAS 1346604-90-7

Fingolimod-d4 HCl (1,3-propane-1,1,3,3-d4-diol)

CAS: 1346604-90-7, 162359-56-0

Purity: 99 atom % D

Molecular weight: 347.96

Ref: 3U-D7971

Fingolimod-d4 Hydrochloride

Controlled Product

CAS: 1346604-90-7

Applications A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),

Formula: C₁₉H₃₀D₄ClNO₂

Color and Shape: Neat

Molecular weight: 347.96

Ref: TR-F805002