CAS 1346617-10-4

Levofloxacin (R)-Ofloxacin-d3

Description:

Levofloxacin (R)-Ofloxacin-d3 is a deuterated derivative of levofloxacin, a broad-spectrum fluoroquinolone antibiotic. It is primarily used in the treatment of bacterial infections by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication and transcription. The deuterated form, indicated by the "d3" in its name, contains three deuterium atoms, which are isotopes of hydrogen. This modification can enhance the stability and metabolic tracking of the compound in biological studies. Levofloxacin itself is characterized by its ability to penetrate tissues effectively, making it suitable for treating respiratory tract infections, urinary tract infections, and skin infections. The compound typically exhibits good oral bioavailability and a favorable pharmacokinetic profile. As with other fluoroquinolones, it may have side effects, including gastrointestinal disturbances and potential effects on tendons. The CAS number 1346617-10-4 uniquely identifies this specific chemical substance in chemical databases, facilitating its study and application in research and clinical settings.

Formula: C₁₈H₁₇D₃FN₃O₄

Synonyms:

• Isoxaben Impurity 39
• Levofloxacin (R)-Ofloxacin-d3

(R)-Ofloxacin-d3

Controlled Product

CAS: 1346617-10-4

Applications A labelled fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).
References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);

Formula: C₁₈₂H₃H₁₇FN₃O₄

Color and Shape: Neat

Molecular weight: 364.39

Ref: TR-O245742