CAS 1346704-33-3

GSK 343

Description:

GSK 343, with the CAS number 1346704-33-3, is a small molecule inhibitor primarily known for its role in the modulation of epigenetic processes. It specifically targets the enzyme EZH2, which is a component of the polycomb repressive complex 2 (PRC2) and is involved in the methylation of histone H3 at lysine 27 (H3K27). This methylation is crucial for gene silencing and regulation of various biological processes, including development and differentiation. GSK 343 has been studied for its potential therapeutic applications in cancer treatment, particularly in tumors with mutations in the EZH2 gene. The compound exhibits selectivity for EZH2 over other methyltransferases, making it a valuable tool in research and drug development. Additionally, its ability to influence gene expression patterns positions it as a significant candidate for further exploration in epigenetic therapies. As with many investigational compounds, the safety and efficacy of GSK 343 are subjects of ongoing research.

Formula: C₃₁H₃₉N₇O₂

InChI: InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)

InChI key: InChIKey=ULNXAWLQFZMIHX-UHFFFAOYSA-N

SMILES: C(NCC1=C(CCC)C=C(C)NC1=O)(=O)C2=C3C(N(C(C)C)N=C3)=CC(=C2)C=4C=C(N=CC4)N5CCN(C)CC5

Synonyms:

• 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide
• 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-
• Gsk 343
• N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide

GSK 343

CAS: 1346704-33-3

Formula: C₃₁H₃₉N₇O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 541.6871

Ref: IN-DA009CC5

N-[(1,2-Dihydro-6-Methyl-2-Oxo-4-Propyl-3-Pyridinyl)Methyl]-1-(1- Methylethyl)-6-[2-(4-Methyl-1-Piperazinyl)-4-Pyridinyl]-1H-Indazole-4-Carboxamide

CAS: 1346704-33-3

N-[(1,2-Dihydro-6-Methyl-2-Oxo-4-Propyl-3-Pyridinyl)Methyl]-1-(1- Methylethyl)-6-[2-(4-Methyl-1-Piperazinyl)-4-Pyridinyl]-1H-Indazole-4-Carboxamide

Purity: 99%+

Molecular weight: 541.69g/mol

Ref: 54-OR1023819

GSK343

CAS: 1346704-33-3

GSK343

Purity: ≥98%

Molecular weight: 541.69g/mol

Ref: 54-BUP10257

GSK343

CAS: 1346704-33-3

GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against

Formula: C₃₁H₃₉N₇O₂

Purity: 98% - 99.9%

Color and Shape: Solid

Molecular weight: 541.69

Ref: TM-T6059

GSK343

CAS: 1346704-33-3

GSK343 is a small-molecule inhibitor, which is synthetically derived with the specific purpose of targeting and inhibiting the activity of the enzyme EZH2, a key component of the Polycomb Repressive Complex 2 (PRC2). This enzyme is responsible for the tri-methylation of histone H3 on lysine 27 (H3K27me3), a modification that plays a crucial role in gene silencing and epigenetic regulation.

Formula: C₃₁H₃₉N₇O₂

Purity: Min. 95%

Molecular weight: 541.7 g/mol

Ref: 3D-WDC70433