CAS 134790-40-2

4-Amino-1-3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone

Description:

4-Amino-1-3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone is a complex organic compound characterized by its unique structural features, including a pyrimidinone ring and a difluorinated sugar moiety. The presence of amino and benzoyl groups contributes to its reactivity and potential biological activity. This compound is notable for its fluorinated sugar, which can enhance its stability and bioavailability in biological systems. The benzoyl groups serve as protecting groups for the hydroxyl functionalities, which can be important in synthetic applications. Its molecular structure suggests potential applications in medicinal chemistry, particularly in the development of antiviral or anticancer agents, due to the presence of the pyrimidine moiety, which is often found in nucleoside analogs. The compound's solubility, stability, and interaction with biological targets would be influenced by its functional groups and stereochemistry. Overall, this substance represents a significant interest in pharmaceutical research and development, particularly in the context of nucleoside analogs.

Formula: C₂₃H₁₉F₂N₃O₆

InChI: InChI=1/C23H19F2N3O6/c24-23(25)18(34-20(30)15-9-5-2-6-10-15)16(13-32-19(29)14-7-3-1-4-8-14)33-21(23)28-12-11-17(26)27-22(28)31/h1-12,16,18,21H,13H2,(H2,26,27,31)/t16-,18+,21-/m1/s1

Synonyms:

• 1’-Epi Gemcitabine 3’,5’-Dibenzoate

1’-Epi gemcitabine 3’,5’-dibenzoate

CAS: 134790-40-2

Ref: 7W-GC6000

1’-Epi Gemcitabine-13C,15N2 3’,5’-Dibenzoate

Controlled Product

CAS: 134790-40-2

Applications A labelled (α-anomer) intermediate of Gemcitabine; antitumor compound.
References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),

Formula: CC₂₂H₁₉F₂₁₅N₂NO₆

Color and Shape: Neat

Molecular weight: 474.39

Ref: TR-E588507

1'-Epi gemcitabine 3',5'-dibenzoate

CAS: 134790-40-2

1'-Epi-Gemcitabine 3',5'-dibenzoate is an analytical standard that is used in the drug development process. It is also a high purity, API impurity, HPLC standard, and drug product. 1'-Epi-Gemcitabine 3',5'-dibenzoate is an impurity of Gemcitabine, which is an anticancer drug. The impurity can be found in the methanolic fraction of the extract and it's an epimer of Gemcitabine. The pharmacopoeia for this compound are USP and EP. Custom synthesis and natural or synthetic are possible for this compound.

Formula: C₂₃H₁₉F₂N₃O₆

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 471.41 g/mol

Ref: 3D-NE16710