8-Aza-6-hydroxy-2-mercaptopurine is a synthetic derivative of purine, characterized by the presence of an azole ring and functional groups that enhance its biological activity. This compound features a hydroxyl group and a mercapto group, which contribute to its potential as a therapeutic agent, particularly in the context of cancer treatment and immunosuppression. The presence of the azole nitrogen atom modifies its electronic properties, influencing its interaction with biological targets, such as enzymes involved in nucleotide metabolism. It is typically studied for its role in inhibiting purine synthesis, which can be beneficial in treating certain malignancies and autoimmune disorders. The compound is soluble in polar solvents, and its stability can be affected by pH and temperature. As with many purine analogs, it may exhibit cytotoxic effects, necessitating careful handling and consideration of dosage in therapeutic applications. Overall, 8-Aza-6-hydroxy-2-mercaptopurine represents a significant compound in medicinal chemistry with potential implications in pharmacology.

8-AZA-6-HYDROXY-2-MERCAPTOPURINE

134811-22-6: 8-Aza-6-hydroxy-2-mercaptopurine is a synthetic derivative of purine, characterized by the presence of an azole ring and functional groups that enhance its biological activity. This compound features a hydroxyl group and a mercapto group, which contribute to its potential as a therapeutic agent, particularly in the context of cancer treatment and immunosuppression. The presence of the azole nitrogen atom modifies its electronic properties, influencing its interaction with biological targets, such as enzymes involved in nucleotide metabolism. It is typically studied for its role in inhibiting purine synthesis, which can be beneficial in treating certain malignancies and autoimmune disorders. The compound is soluble in polar solvents, and its stability can be affected by pH and temperature. As with many purine analogs, it may exhibit cytotoxic effects, necessitating careful handling and consideration of dosage in therapeutic applications. Overall, 8-Aza-6-hydroxy-2-mercaptopurine represents a significant compound in medicinal chemistry with potential implications in pharmacology.

<p>8-Aza-6-hydroxy-2-mercaptopurine (8AzaMP) is a novel nucleoside analog that is an activator of the thymidylate synthase enzyme. It has been shown to inhibit the replication of many DNA viruses and to inhibit tumor growth in animal models. 8AZA MP has been evaluated in Phase I and II clinical trials for the treatment of various cancers, including malignant melanoma, renal cell carcinoma, and chronic lymphocytic leukemia. This drug has also shown promise as a chemotherapeutic agent for AIDS patients with HIV infection or AIDS-related complex.</p>

CAS 134811-22-6

8-AZA-6-HYDROXY-2-MERCAPTOPURINE

8-Aza-6-hydroxy-2-mercaptopurine

Ref: 3D-NA66851