Gastric inhibitory polypeptide fragment 1-30 amide, also known as GIP, is a peptide hormone that plays a crucial role in glucose metabolism and insulin secretion. It is primarily produced in the K cells of the duodenum and jejunum in response to food intake, particularly fats and carbohydrates. The fragment 1-30 refers to the specific amino acid sequence of the peptide, which is essential for its biological activity. As an amidated peptide, it possesses an amide group at its C-terminus, which enhances its stability and bioactivity. GIP functions by inhibiting gastric acid secretion and promoting insulin release from the pancreas, thereby contributing to the regulation of blood glucose levels. Its action is part of the incretin effect, where hormones released from the gut enhance insulin response after meals. The CAS number 134846-93-8 uniquely identifies this specific peptide, facilitating its recognition in scientific literature and databases. Overall, GIP is significant in metabolic processes and has implications for understanding conditions like obesity and type 2 diabetes.

gastric inhibitory polypeptide fragment 1-30 amid

134846-93-8: Gastric inhibitory polypeptide fragment 1-30 amide, also known as GIP, is a peptide hormone that plays a crucial role in glucose metabolism and insulin secretion. It is primarily produced in the K cells of the duodenum and jejunum in response to food intake, particularly fats and carbohydrates. The fragment 1-30 refers to the specific amino acid sequence of the peptide, which is essential for its biological activity. As an amidated peptide, it possesses an amide group at its C-terminus, which enhances its stability and bioactivity. GIP functions by inhibiting gastric acid secretion and promoting insulin release from the pancreas, thereby contributing to the regulation of blood glucose levels. Its action is part of the incretin effect, where hormones released from the gut enhance insulin response after meals. The CAS number 134846-93-8 uniquely identifies this specific peptide, facilitating its recognition in scientific literature and databases. Overall, GIP is significant in metabolic processes and has implications for understanding conditions like obesity and type 2 diabetes.

This GIP fragment has potent insulinotropic activity in the isolated, perfused rat pancreas but greatly reduced somatostatinotropic activity in the isolated perfused rat stomach. The site responsible for insulinotropic activity apparently lies between residues 19 and 30 of GIP.

Gastric Inhibitory Polypeptide (1-30) amide (porcine)

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CAS 134846-93-8

gastric inhibitory polypeptide fragment 1-30 amid

Gastric Inhibitory Polypeptide (1-30) amide (porcine)

Ref: 01-4030659

Gastric Inhibitory Polypeptide (1-30) amide (porcine)

Ref: 3D-FG109097