CAS 134861-62-4

dioxamycin

Description:

Dioxamycin, with the CAS number 134861-62-4, is a synthetic antibiotic that belongs to the class of compounds known as anthracyclines. It is characterized by its complex polycyclic structure, which is essential for its biological activity. Dioxamycin exhibits potent antitumor properties, primarily by intercalating into DNA and inhibiting topoisomerase II, leading to disruption of DNA replication and transcription. This mechanism makes it a valuable compound in cancer therapy. The substance is typically administered in a clinical setting and has been studied for its efficacy against various types of cancer. Additionally, dioxamycin may exhibit side effects common to anthracyclines, such as cardiotoxicity and myelosuppression, necessitating careful monitoring during treatment. Its solubility and stability in different solvents can influence its formulation and delivery methods. Overall, dioxamycin represents a significant compound in the field of medicinal chemistry, particularly in the development of chemotherapeutic agents.

Formula: C₃₈H₄₀O₁₅

Synonyms:

• 1,3-Dioxolane-2-carboxylic acid, 2,4-dimethyl-5-[(1E,3E,5E)-7-oxo-7-[[(2R,3S,6R)-tetrahydro-2-methyl-6-[(2R,3R,4aR,12bS)-1,2,3,4,4a,7,12,12b-octahydro-2,3,4a,8,12b-pentahydroxy-3-methyl-1,7,12-trioxobenz[a]anthracen-9-yl]-2H-pyran-3-yl]oxy]-1,3,5-heptatrien-1-yl]-, (2S,4S,5S)-rel-(+)-
• dioxamycin

Dioxamycin

CAS: 134861-62-4

Dioxamycin exhibits activity against Gram-positive bacteria and inhibits Staphylococcus aureus 209P with a minimum inhibitory concentration (MIC) of 3.12 μg/mL. It also suppresses the proliferation of L1210, P388, IMC, LX-1, and SC-6 cells with IC50 values (μg/mL) of 2.7, 1.4, 6.0, 2.0, and 2.5, respectively.

Formula: C₃₈H₄₀O₁₅

Color and Shape: Solid

Molecular weight: 736.715

Ref: TM-TN10622