CAS 135-07-9

Methyclothiazide

Description:

Methyclothiazide is a thiazide diuretic commonly used in the treatment of hypertension and edema. It functions by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, thereby reducing blood volume and blood pressure. The chemical formula for Methyclothiazide is C8H9ClN2O4S, and it features a thiazide ring structure, which is characteristic of this class of diuretics. The substance is typically presented as a white to off-white crystalline powder, and it is slightly soluble in water, with better solubility in organic solvents. Methyclothiazide has a moderate half-life, allowing for once-daily dosing in clinical practice. Its pharmacological effects can lead to electrolyte imbalances, particularly hypokalemia, necessitating monitoring of potassium levels during treatment. Additionally, it may interact with other medications, so careful consideration of a patient's overall medication regimen is essential. Overall, Methyclothiazide is an effective agent in managing fluid retention and high blood pressure, contributing to cardiovascular health.

Formula: C₉H₁₁Cl₂N₃O₄S₂

InChI: InChI=1S/C9H11Cl2N3O4S2/c1-14-9(4-10)13-6-2-5(11)7(19(12,15)16)3-8(6)20(14,17)18/h2-3,9,13H,4H2,1H3,(H2,12,15,16)

InChI key: InChIKey=CESYKOGBSMNBPD-UHFFFAOYSA-N

SMILES: O=S1(=O)C=2C(NC(CCl)N1C)=CC(Cl)=C(S(N)(=O)=O)C2

Synonyms:

• 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• 6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
• 6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide
• 6-Chloro-3-chloromethyl-3,4-dihydro-2-methyl-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
• Aquatensen
• Ciba 7272-Su
• Duretic
• Enduron
• Enduronum
• Eutron
• Methyclothiazid
• Methyclothiazide
• Methycyclothiazide
• Methylcyclothiazide
• Meticlotiazida
• Naturon
• Nsc 110431
• 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide
• 2-methyl-3-chloromethylhydrochlorothiazide

Methyclothiazide

CAS: 135-07-9

Color and Shape: Off-White

Ref: 61-FOR1334.00

Methyclothiazide

CAS: 135-07-9

Sulfonamides used as drugs

Formula: C₉H₁₁Cl₂N₃O₄S₂

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 360.24 g/mol

Ref: 45-1424007

2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

CAS: 135-07-9

Formula: C₉H₁₁Cl₂N₃O₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 360.2373

Ref: IN-DA00HTU3

Methyclothiazide

CAS: 135-07-9

Methyclothiazide

Purity: ≥95%

Molecular weight: 360.24g/mol

Ref: 54-BUP16406

Methyclothiazide

CAS: 135-07-9

Formula: C₉H₁₁Cl₂N₃O₄S₂

Molecular weight: 360.24

Ref: 7W-GP4394

Methyclothiazide

CAS: 135-07-9

Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including

Formula: C₉H₁₁Cl₂N₃O₄S₂

Purity: 99.13%

Color and Shape: Solid

Molecular weight: 360.24

Ref: TM-T6581

Methyclothiazide

Controlled Product

CAS: 135-07-9

Applications Methyclothiazid, is derivative of Hydrochlorothiazide (H714560), which is a diuretic used in the hospital or for personal use to promote excess fluid associated with congestive heart failure. It is also used as an antihypertensive.
References Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961), Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),

Formula: C₉H₁₁Cl₂N₃O₄S₂

Color and Shape: Off-White

Molecular weight: 360.24

Ref: TR-M260155

Methyclothiazide-13C6

Controlled Product

CAS: 135-07-9

Formula: C₃C₆H₁₁Cl₂N₃O₄S₂

Color and Shape: Neat

Molecular weight: 366.19

Ref: TR-M260157