CAS 135-16-0

Tetrahydrofolic acid

Description:

Tetrahydrofolic acid, also known as tetrahydrofolate (THF), is a water-soluble B-vitamin derivative that plays a crucial role in cellular metabolism, particularly in the synthesis of nucleic acids and amino acids. It is the active form of folate, which is essential for DNA synthesis, repair, and methylation, making it vital for cell division and growth. Tetrahydrofolic acid is characterized by its ability to accept and donate one-carbon units in various biochemical reactions, facilitating the conversion of homocysteine to methionine and the synthesis of purines and thymidine. The compound is typically found in the body as a coenzyme in the form of various polyglutamate derivatives, enhancing its stability and activity. In terms of physical properties, tetrahydrofolic acid is a pale yellow to orange crystalline powder that is soluble in water but relatively insoluble in organic solvents. Its deficiency can lead to megaloblastic anemia and other health issues, underscoring its importance in nutrition and health.

Formula: C₁₉H₂₃N₇O₆

InChI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

InChI key: InChIKey=MSTNYGQPCMXVAQ-KIYNQFGBSA-N

SMILES: O=C1C2=C(NCC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)N2)NC(N)=N1

Synonyms:

• (-)-<span class="text-smallcaps">L</span>-5,6,7,8-Tetrahydrofolic acid
• (-)-L-5,6,7,8-Tetrahydrofolic acid
• (2S)-2-(4-(((2-Imino-4-oxo-1,2,3,4,5,6,7,8-octahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid
• 5,6,7,8-Tetrahydrofolic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Glutamic acid, N-[p-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, L-
• L-Glutamic acid, N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• N-[4-[[(2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsaure
• N-[4-[[(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• Tetrahydrofolic acid
• Tetrahydropteroylglutamic acid
• Thfa
• acide N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamique
• acido N-[4-[[(2-amino-1,4,5,6,7,8-hexahidro-4-oxo-6-pteridinil)metil]amino]benzoil]-L-glutamico
• L-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-

Tetrahydrofolic acid

CAS: 135-16-0

Formula: C₁₉H₂₃N₇O₆

Purity: 67%

Color and Shape: Solid

Molecular weight: 445.4292

Ref: IN-DA009BK3

Tetrahydrofolic acid

CAS: 135-16-0

Tetrahydrofolic acid

Formula: C₁₉H₂₃N₇O₆

Purity: 67%

Color and Shape: brown solid

Molecular weight: 445.43g/mol

Ref: 54-BIT3012

Tetrahydrofolic acid

CAS: 135-16-0

Formula: C₁₉H₂₃N₇O₆

Purity: ≥ 65%

Color and Shape: Faint yellow, faint brown or brown powder or solid

Molecular weight: 445.43

Ref: 7W-GV7828

Tetrahydrofolic acid

CAS: 135-16-0

Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) is a VB9 derivative that is a common one-carbon donor in organisms and is involved in growth and metabolism.

Formula: C₁₉H₂₃N₇O₆

Purity: 94.10% - 94.61%

Color and Shape: Solid

Molecular weight: 445.43

Ref: TM-T21367

Tetrahydrofolic Acid

CAS: 135-16-0

Formula: C₁₉H₂₃N₇O₆

Molecular weight: 445.44

Ref: 4Z-F-2419

L-Tetrahydrofolic Acid (>70% when packaged)

Controlled Product

CAS: 135-16-0

Stability We have observed that this material decomposes steadily over time. Use immediate
Applications L-Tetrahydrofolic Acid is a folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids. We have observed that this material decomposes steadily over time. Use immediately upon receipt.
References Prinz-Langenohl, R., et al.: Brit. J. Pharmacol., 158, 2014 (2009), Martin, H., et al.: Anal. Biochem., 402, 137 (2010), Dasarathy, J., et al.: Am. J. Clin. Nut., 91, 357 (2010), Karas-Kuzelicki, N., et al.: Clin. Biochem., 43, 37 (2010),

Formula: C₁₉H₂₃N₇O₆

Color and Shape: Neat

Molecular weight: 445.43

Ref: TR-T293515

Tetrahydrofolic Acid

CAS: 135-16-0

Purity: 67.0%

Molecular weight: 445.436

Ref: 10-F544915

Tetrahydrofolic acid

CAS: 135-16-0

Tetrahydrofolic acid is a water-soluble sodium salt that is found in the form of tetrahydrofolate (THF) in the human body. It is involved in the synthesis of DNA and other biomolecules. Tetrahydrofolic acid has been used as an antimicrobial agent, mainly to inhibit bacterial growth. In wastewater treatment, tetrahydrofolic acid has been shown to have a matrix effect on polymerization reactions and transfer reactions. Tetrahydrofolic acid can also be used as a reagent for analytical methods and reaction solutions for enzymes with THF as a substrate. The enzyme activities are glycol ethers with THF as a cofactor. Tetrahydrofolic acid can be used in model systems to study enzyme kinetics or enzymatic mechanisms.

Formula: C₁₉H₂₃N₇O₆

Purity: 65%Min

Molecular weight: 445.43 g/mol

Ref: 3D-FT165435

L-Tetrahydrofolic Acid

CAS: 135-16-0

Formula: C₁₉H₂₃N₇O₆

Molecular weight: 445.40

Ref: ST-EA-CP-F5018