CAS 135038-57-2

Fasidotril

Description:

Fasidotril, identified by its CAS number 135038-57-2, is a chemical compound that functions primarily as an angiotensin-converting enzyme (ACE) inhibitor. It is characterized by its ability to modulate the renin-angiotensin system, which plays a crucial role in regulating blood pressure and fluid balance. Fasidotril is notable for its dual action, as it not only inhibits ACE but also has effects on bradykinin metabolism, potentially leading to vasodilation and improved cardiovascular outcomes. The compound is typically administered in a pharmaceutical context, often in formulations aimed at treating conditions such as hypertension and heart failure. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its efficacy and safety profile. As with many ACE inhibitors, potential side effects may include cough, elevated potassium levels, and hypotension. Overall, Fasidotril represents a significant therapeutic option within the class of antihypertensive agents, contributing to the management of cardiovascular diseases.

Formula: C₂₃H₂₅NO₆S

InChI: InChI=1/C23H25NO6S/c1-15(23(27)28-12-17-6-4-3-5-7-17)24-22(26)19(13-31-16(2)25)10-18-8-9-20-21(11-18)30-14-29-20/h3-9,11,15,19H,10,12-14H2,1-2H3,(H,24,26)/t15-,19+/m0/s1

Synonyms:

• benzyl N-[(2S)-3-(acetylsulfanyl)-2-(1,3-benzodioxol-5-ylmethyl)propanoyl]-L-alaninate
• N-((S)-alpha-(Mercaptomethyl)-3,4-(methylenedioxy)hydrocinnamoyl)-L-alanine, benzyl ester acetate (ester)
• Alatriopril
• L-Alanine, N-(3-(acetylthio)-2-(1,3-benzodioxol-5-ylmethyl)-1-oxopropyl)-, phenylmethyl ester, (S)-
• N-(3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-oxopropyl)-(S)-alanine benzyl ester
• UNII-BIB7HG2V9E

Fasidotril

CAS: 135038-57-2

Fasidotril inhibits NEP/ACE, treats high blood pressure in rats, effective in humans with hypertension.

Formula: C₂₃H₂₅NO₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 443.51

Ref: TM-T27306