CAS 1350514-68-9

MK 5172

Description:

MK-5172, also known as Grazoprevir, is a potent and selective inhibitor of the hepatitis C virus (HCV) NS3/4A protease, which plays a crucial role in the viral replication process. This compound is characterized by its ability to effectively inhibit the replication of various HCV genotypes, making it a valuable component in antiviral therapy. MK-5172 is typically administered in combination with other antiviral agents to enhance its efficacy and reduce the potential for resistance. The substance is known for its favorable pharmacokinetic profile, including good oral bioavailability and a relatively long half-life, which supports once-daily dosing. Additionally, it has been evaluated in clinical trials for its safety and tolerability, showing a manageable side effect profile. As a small molecule drug, MK-5172 is synthesized through complex organic chemistry processes, and its development represents a significant advancement in the treatment of chronic hepatitis C infection.

Formula: C₃₈H₅₀N₆O₉S

InChI: InChI=1S/C38H50N6O9S/c1-6-22-19-38(22,35(47)43-54(49,50)25-13-14-25)42-32(45)29-18-24-20-44(29)34(46)31(37(2,3)4)41-36(48)53-30-16-21(30)10-8-7-9-11-27-33(52-24)40-28-17-23(51-5)12-15-26(28)39-27/h6,12,15,17,21-22,24-25,29-31H,1,7-11,13-14,16,18-20H2,2-5H3,(H,41,48)(H,42,45)(H,43,47)/t21-,22-,24-,29+,30-,31-,38-/m1/s1

InChI key: InChIKey=OBMNJSNZOWALQB-NCQNOWPTSA-N

SMILES: N(C(=O)[C@H]1N2C[C@@](C1)(OC=3C(=NC=4C(N3)=CC(OC)=CC4)CCCCC[C@]5([C@](OC(=O)N[C@@H]([C@@](C)(C)C)C2=O)(C5)[H])[H])[H])[C@@]6(C(NS(=O)(=O)C7CC7)=O)[C@H](C=C)C6

Synonyms:

• Grazoprevir
• MK 5172
• Cyclopropanecarboxamide, N-[[[(1R,2R)-2-[5-(3-hydroxy-6-methoxy-2-quinoxalinyl)pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, cyclic (1→2)-ether, (1R,2S)-

MK5172

CAS: 1350514-68-9

Formula: C₃₈H₅₀N₆O₉S

Purity: 98%

Color and Shape: Solid

Molecular weight: 766.9034

Ref: IN-DA009CDB

Grazoprevir

CAS: 1350514-68-9

Formula: C₃₈H₅₀N₆O₉S

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 766.90

Ref: 7W-GP1475

Grazoprevir

CAS: 1350514-68-9

Grazoprevir

Purity: ≥98%

Molecular weight: 766.9g/mol

Ref: 54-BUP12894

Grazoprevir

CAS: 1350514-68-9

Grazoprevir (MK-5172) is a protease inhibitor targeting hepatitis C virus NS3/4A used for treating chronic HCV genotypes 1 or 4 infections. Cost-effective and quality-assured.

Formula: C₃₈H₅₀N₆O₉S

Purity: 99.36% - >99.99%

Color and Shape: Solid

Molecular weight: 766.9

Ref: TM-T4547

Grazoprevir

CAS: 1350514-68-9

Anti-viral; inhibits Hepatitis C virus NS3/4a protease

Formula: C₃₈H₅₀N₆O₉S

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 766.9 g/mol

Ref: 3D-FG74818

Grazoprevir

CAS: 1350514-68-9

Purity: 98%

Molecular weight: 766.91

Ref: 10-F979807

Grazoprevir-D4 (MK 5172-D4)

Controlled Product

CAS: 1350514-68-9

Formula: C₃₈D₄H₄₆N₆O₉S

Color and Shape: Neat

Molecular weight: 770.928

Ref: TR-M424987

Grazoprevir

CAS: 1350514-68-9

Applications MK 5172, also known as Grazoprevir, is a second-generation NS3/4A protease inhibitor that is often used in combination with the second-generation NS5A inhibitor, Elbasvir (E501010), for the treatment of hepatitis C virus infection. It is a COVID19-related research product.
References Alric, L., et al.: Expert Opin. Pharmaco., 17, 735 (2016); Gentile, I., et al.: Expert Opin. Inv. Drug., 25, 557 (2016); Sulejmani, N., et al.: Expert Opin. Drug Met., 12, 353 (2016); Roensholt, F.F., et al.: Future Virol., 10, 691 (2015)

Formula: C₃₈H₅₀N₆O₉S

Color and Shape: White To Off-White

Molecular weight: 766.90

Ref: TR-M424985