CAS 1350653-20-1

Vericiguat

Description:

Vericiguat is a small molecule that functions as a soluble guanylate cyclase (sGC) stimulator, primarily used in the treatment of heart failure. It enhances the sensitivity of sGC to nitric oxide, leading to increased levels of cyclic guanosine monophosphate (cGMP), which promotes vasodilation and reduces cardiac workload. The chemical structure of Vericiguat includes a unique combination of functional groups that contribute to its pharmacological activity. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. The substance is characterized by its ability to improve hemodynamics and exercise capacity in patients with heart failure, making it a valuable therapeutic option. Additionally, Vericiguat has undergone extensive clinical trials to establish its efficacy and safety profile, demonstrating a significant impact on reducing the risk of cardiovascular events. As with any medication, potential side effects and contraindications should be considered, and it is essential for patients to consult healthcare professionals for personalized medical advice.

Formula: C₁₉H₁₆F₂N₈O₂

InChI: InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)

InChI key: InChIKey=QZFHIXARHDBPBY-UHFFFAOYSA-N

SMILES: C(N1N=C(C=2C1=NC=C(F)C2)C=3N=C(N)C(NC(OC)=O)=C(N)N3)C4=C(F)C=CC=C4

Synonyms:

• Methyl N-[4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
• Carbamic acid, N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester
• Vericiguat
• Methyl [4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
• BAY 1021189
• Vericiguat (BAY 1021189)
• Avatrombopag Maleate
• MK-1242
• BAY1021189

Methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate

CAS: 1350653-20-1

Formula: C₁₉H₁₆F₂N₈O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 426.3795

Ref: IN-DA00HTVG

Methyl (4,6-Diamino-2-(5-Fluoro-1-(2-Fluorobenzyl)-1H-Pyrazolo[3,4-B]Pyridin-3-Yl)Pyrimidin-5-Yl)Carbamate

CAS: 1350653-20-1

Methyl (4,6-Diamino-2-(5-Fluoro-1-(2-Fluorobenzyl)-1H-Pyrazolo[3,4-B]Pyridin-3-Yl)Pyrimidin-5-Yl)Carbamate

Purity: 99%

Molecular weight: 426.38g/mol

Ref: 54-PC108879

Vericiguat-d6

CAS: 1350653-20-1

Formula: C₁₉H₁₀D₆F₂N₈O₂

Molecular weight: 432.42

Ref: 4Z-V-092004

Vericiguat-13C-d3

CAS: 1350653-20-1

Formula: C₁₈₁₃CH₁₃D₃F₂N₈O₂

Color and Shape: White To Off-White Solid

Molecular weight: 430.40

Ref: 4Z-V-092003

Vericiguat

CAS: 1350653-20-1

Formula: C₁₉H₁₆F₂N₈O₂

Molecular weight: 426.39

Ref: 4Z-V-092001

Vericiguat

CAS: 1350653-20-1

Vericiguat

Purity: ≥98%

Molecular weight: 426.38g/mol

Ref: 54-BUP09308

Vericiguat-d3

CAS: 1350653-20-1

Formula: C₁₉H₁₃D₃F₂N₈O₂

Molecular weight: 429.41

Ref: 4Z-V-092002

Vericiguat

CAS: 1350653-20-1

Vericiguat (BAY1021189) is a potent and orally available guanylate cyclase stimulator.

Formula: C₁₉H₁₆F₂N₈O₂

Purity: 98.86% - 99.93%

Color and Shape: Solid

Molecular weight: 426.38

Ref: TM-T17226

Vericiguat

Controlled Product

CAS: 1350653-20-1

Formula: C₁₉H₁₆F₂N₈O₂

Color and Shape: Neat

Molecular weight: 426.38

Ref: TR-V415235