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CAS 1350653-20-1

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Vericiguat

Description:
Vericiguat is a small molecule that functions as a soluble guanylate cyclase (sGC) stimulator, primarily used in the treatment of heart failure. It enhances the sensitivity of sGC to nitric oxide, leading to increased levels of cyclic guanosine monophosphate (cGMP), which promotes vasodilation and reduces cardiac workload. The chemical structure of Vericiguat includes a unique combination of functional groups that contribute to its pharmacological activity. It is typically administered orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. The substance is characterized by its ability to improve hemodynamics and exercise capacity in patients with heart failure, making it a valuable therapeutic option. Additionally, Vericiguat has undergone extensive clinical trials to establish its efficacy and safety profile, demonstrating a significant impact on reducing the risk of cardiovascular events. As with any medication, potential side effects and contraindications should be considered, and it is essential for patients to consult healthcare professionals for personalized medical advice.
Formula:C19H16F2N8O2
InChI:InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)
InChI key:InChIKey=QZFHIXARHDBPBY-UHFFFAOYSA-N
SMILES:C(N1N=C(C=2C1=NC=C(F)C2)C=3N=C(N)C(NC(OC)=O)=C(N)N3)C4=C(F)C=CC=C4
Synonyms:
  • Methyl N-[4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
  • Carbamic acid, N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester
  • Vericiguat
  • Methyl [4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
  • BAY 1021189
  • Vericiguat (BAY 1021189)
  • Avatrombopag Maleate
  • MK-1242
  • BAY1021189
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Found 9 products.