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CAS 135197-63-6

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3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine

Description:
3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine is a modified nucleoside that features a fluorine atom at the 3' position of the sugar moiety, which alters its biochemical properties compared to natural thymidine. The presence of the trityl group at the 5' position provides protection against enzymatic degradation, making it useful in synthetic applications, particularly in the field of oligonucleotide synthesis. This compound is characterized by its ability to participate in nucleic acid interactions while exhibiting enhanced stability and resistance to nucleases. The fluorine substitution can influence the compound's hydrogen bonding capabilities and overall molecular conformation, potentially affecting its biological activity. Additionally, the trityl protecting group can be selectively removed under specific conditions, allowing for further functionalization or incorporation into larger nucleic acid structures. Overall, 3'-Deoxy-3'-fluoro-5'-O-trityl-D-thymidine serves as a valuable tool in molecular biology and medicinal chemistry, particularly in the development of antiviral and anticancer therapies.
Formula:C29H27FN2O4
InChI:InChI=1/C29H27FN2O4/c1-20-18-32(28(34)31-27(20)33)26-17-24(30)25(36-26)19-35-29(21-11-5-2-6-12-21,22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,18,24-26H,17,19H2,1H3,(H,31,33,34)/t24-,25-,26-/m1/s1
SMILES:Cc1cn([C@H]2C[C@H]([C@@H](COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)F)c(=O)nc1O
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Found 2 products.
  • 3''-Deoxy-3''-fluoro-5''-O-tritylthymidine
    Glentham
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    3''-Deoxy-3''-fluoro-5''-O-tritylthymidine

    CAS:

    Ref: 7W-GN3840

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  • 3'-Deoxy-3'-fluoro-5'-O-tritylthymidine
    Biosynth
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    3'-Deoxy-3'-fluoro-5'-O-tritylthymidine

    CAS:
    <p>3'-Deoxy-3'-fluoro-5'-O-tritylthymidine is a monophosphate nucleoside that inhibits the viral DNA polymerase. It has antiviral activity against herpes viruses, including HSV-1 and HSV-2. 3'-Deoxy-3'-fluoro-5'-O-tritylthymidine is a synthetic nucleoside with modified phosphate groups to improve stability and purity. This product has shown anticancer effects in vitro and in vivo by inhibiting DNA synthesis and promoting apoptosis of cancer cells.</p>
    Formula:C29H27FN2O4
    Purity:Min. 95%
    Molecular weight:486.53 g/mol

    Ref: 3D-ND04744

    25mg
    303.00€
    50mg
    310.00€
    100mg
    502.00€