CAS 1352066-68-2
:AMG232
Description:
AMG232, also known by its chemical name, is a small molecule inhibitor that specifically targets the protein MDM2 (Mouse Double Minute 2 homolog), which is a negative regulator of the p53 tumor suppressor pathway. This compound is classified as an antineoplastic agent and has been investigated for its potential use in cancer therapy, particularly in tumors that express wild-type p53. AMG232 functions by disrupting the interaction between MDM2 and p53, thereby stabilizing p53 and promoting its tumor-suppressive activities, such as inducing cell cycle arrest and apoptosis in cancer cells. The substance is typically characterized by its molecular structure, which includes specific functional groups that facilitate its binding to the MDM2 protein. In preclinical studies, AMG232 has shown promise in various cancer models, leading to ongoing research to evaluate its efficacy and safety in clinical settings. As with many investigational drugs, its pharmacokinetics, dosing, and potential side effects are subjects of active investigation.
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 5 products.
Navtemadlin
CAS:<p>Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM).Cost-effective and quality-assured.</p>Formula:C28H35Cl2NO5SPurity:95.55% - 99.08%Color and Shape:SolidMolecular weight:568.55AMG 232
CAS:<p>Inhibits MDM2-p53 interaction</p>Formula:C28H35Cl2NO5SPurity:Min. 95%Molecular weight:568.55 g/mol
