CAS 1352226-88-0

AZD6738

CAS: 1352226-88-0

Formula: C₂₀H₂₄N₆O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 412.5086

Ref: IN-DA009CGY

Ceralasertib

CAS: 1352226-88-0

Ceralasertib

Purity: ≥98%

Molecular weight: 412.51g/mol

Ref: 54-BUP14387

Ceralasertib

CAS: 1352226-88-0

Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.

Formula: C₂₀H₂₄N₆O₂S

Purity: 98% - 99.99%

Color and Shape: Solid

Molecular weight: 412.51

Ref: TM-T3338

AZD6738

Controlled Product

CAS: 1352226-88-0

Applications AZD6738 is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. In addition, AZD6738 sensitizes tumor cells to chemo- and radiotherapy. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression, and survival; it is activated by DNA damage caused during DNA r
References Karnitz, Larry M., et al.: Clin Cancer Res., 21, 4780 (2015); Kwok, Marwan., et al.: Blood., 127, 582 (2016)

Formula: C₂₀H₂₄N₆O₂S

Color and Shape: Neat

Molecular weight: 412.51

Ref: TR-A965423

AZD 6738

CAS: 1352226-88-0

Inhibitor of serine/threonine protein kinase ATM and ATR kinases

Formula: C₂₀H₂₄N₆O₂S

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 412.51 g/mol

Ref: 3D-FA145496