CAS 1352328-65-4

Chol-​6-​en-​24-​oic acid, 3,​7-​bis[(trimethylsilyl)​oxy]​-​, phenylmethyl ester, (3α,​5β)​-

Description:

Chol-6-en-24-oic acid, 3,7-bis[(trimethylsilyl)oxy]-, phenylmethyl ester, (3α,5β)- is a synthetic derivative of cholesterol, characterized by the presence of a cholestane backbone with specific functional groups that enhance its solubility and reactivity. This compound features two trimethylsilyl ether groups, which provide increased stability and hydrophobicity, making it suitable for various applications in organic synthesis and biochemistry. The phenylmethyl ester moiety contributes to its lipophilicity and potential interactions with biological membranes. The stereochemistry indicated by (3α,5β) suggests specific spatial arrangements of the substituents, which can influence the compound's biological activity and interaction with enzymes or receptors. This compound may be of interest in pharmaceutical research, particularly in the development of cholesterol-related drugs or as a biochemical probe. Its unique structural characteristics, including the presence of multiple functional groups, allow for diverse reactivity and potential applications in medicinal chemistry and materials science.

Formula: C₃₇H₆₀O₄Si₂

Phenylmethyl 3,7-Bis[(trimethylsilyl)oxy]-chol-6-en-24-oic Acid Ester

Controlled Product

CAS: 1352328-65-4

Applications Phenylmethyl 3,7-Bis[(trimethylsilyl)oxy]-chol-6-en-24-oic Acid Ester is an intermediate used in the synthesis of 6-Ethylchenodeoxycholic-d5 Acid (E899812), which is an isotope labelled compound of 6-Ethylchenodeoxycholic Acid (E899810), which is used in the investigative treatment of primary biliary cholangitis. Primary biliary cholangitis is an autoimmune disease of the liver that slowly progresses to cirrhosis.
References Ali, A. H, et al.: Expert Opin. Orphan Drugs, 4, 1011 (2016)

Formula: C₃₇H₆₀O₄Si₂

Color and Shape: Neat

Molecular weight: 625.041

Ref: TR-P404360