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CAS 135306-85-3

:

(tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment 4-1

Description:
The chemical substance known as "(tyr5,D-trp6,8,9,lys10)-A-neurokinin*fragment 4-1," with the CAS number 135306-85-3, is a synthetic peptide that is a fragment of the neurokinin A (NKA) family. This peptide is characterized by its specific amino acid sequence, which includes modifications such as the incorporation of D-tryptophan at positions 6, 8, and 9, and lysine at position 10, contributing to its biological activity and stability. Neurokinins are involved in various physiological processes, including pain perception, inflammation, and neurogenic responses. The structural modifications in this peptide enhance its receptor binding affinity and may influence its pharmacological properties. Typically, such peptides are studied for their potential therapeutic applications in conditions like pain management and neurogenic inflammation. The presence of aromatic and basic amino acids in its structure suggests potential interactions with neurokinin receptors, making it a subject of interest in neuropharmacology and peptide research.
Formula:C57H68N12O10
InChI:InChI=1/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)/t40-,44-,45-,46+,47+,48+,50-/m0/s1
Synonyms:
  • Men 10376
  • Neurokinin A(4-10), tyr(5)-trp(6,8,9)-lys(10)-
  • 5-Tyr-6,8,9-trp-10-lys-neurokinin A (4-10)
  • Neurokinin A(4-10), tyrosyl(5)-tryptophyl(6,8,9)-lysine(10)-
  • L-Lysinamide, L-alpha-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-
  • L-alpha-aspartyl-L-tyrosyl-D-tryptophyl-L-valyl-D-tryptophyl-D-tryptophyl-L-lysinamide
  • (Tyr5,D-Trp6'8'9,Lys-NH210)-Neurokinin A (4-10)
  • (Tyr5,D-Trp689,Lys-NH210)-Neurokinin A (4-10)
  • H-Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2
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