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CAS 135326-55-5

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CLARITHROMYCIN LACTOBIONATE

Description:
Clarithromycin lactobionate is a macrolide antibiotic derived from erythromycin, primarily used for its antibacterial properties. It is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, making it effective against a range of Gram-positive and some Gram-negative bacteria. The lactobionate form enhances its solubility and stability, which is particularly beneficial for intravenous administration. This compound is often utilized in the treatment of respiratory tract infections, skin infections, and certain types of bacterial infections, including those caused by Helicobacter pylori. Clarithromycin lactobionate is generally well-tolerated, but like other antibiotics, it may cause side effects such as gastrointestinal disturbances and potential interactions with other medications due to its metabolism via the cytochrome P450 system. Its pharmacokinetics allow for good tissue penetration, contributing to its efficacy in treating infections. As with any antibiotic, appropriate use is crucial to prevent the development of antibiotic resistance.
Formula:C50H89NO24
InChI:InChI=1/C38H69NO13.C12H22O12/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27;13-1-3(15)10(7(18)8(19)11(21)22)24-12-9(20)6(17)5(16)4(2-14)23-12/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3;3-10,12-20H,1-2H2,(H,21,22)/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-;3-,4-,5+,6+,7-,8-,9-,10-,12+/m11/s1
Synonyms:
  • (2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}hexanoic acid - (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (1:1) (non-preferred name)
  • (3R,4S,5S,6R,7R,9R,11R,12R,13R,14R)-6-[(2S,3R,4S,6R)-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2S,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
  • CLARITHROMYCIN LACTOBIONATE
  • Erythromycin, 6-O-methyl-, 4-O-beta-D-galactopyranosyl-D-gluconate (salt)
  • (2R,3S,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanoic acid
  • D-Gluconic acid, 4-O-beta-D-galactopyranosyl-, compd with 6-O-methylerythromycin (1:1)
  • Clarithromycin lactobionate
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