CAS 13539-59-8

Apazone

Description:

Apazone, with the CAS number 13539-59-8, is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of pyrazolone derivatives. It is primarily recognized for its analgesic and anti-inflammatory properties, making it useful in the treatment of pain and inflammatory conditions. Apazone functions by inhibiting the cyclooxygenase (COX) enzymes, which play a crucial role in the synthesis of prostaglandins, compounds that mediate inflammation and pain. The substance is characterized by its relatively low solubility in water, which can affect its bioavailability and absorption in the body. Additionally, Apazone may exhibit side effects typical of NSAIDs, such as gastrointestinal discomfort or potential renal effects, necessitating careful consideration in its therapeutic use. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are important for understanding its efficacy and safety profile. Overall, Apazone represents a significant compound in the realm of pain management and inflammation control, although its use may be limited by potential adverse effects.

Formula: C₁₆H₂₀N₄O₂

InChI: InChI=1/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3

InChI key: InChIKey=MPHPHYZQRGLTBO-UHFFFAOYSA-N

SMILES: O=C1N2N(C(N(C)C)=NC=3C2=CC(C)=CC3)C(=O)C1CCC

Synonyms:

• 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-
• 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine
• 5-(dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione
• Ahr 3018
• Azapropazone
• Cinnamin
• Cinnopropazone
• Mi 85
• NSC 102824
• Prolixan
• Sinnamin
• Apazone
• AZAPROPAZONE IMPURITY B BP(CRM STANDARD)
• Rheumox
• AZAPROPAZONE BP STANDARD(CRM STANDARD)
• AZAPROPAZONE IMPURITY C BP(CRM STANDARD)
• AZAPROPAZONE IMPURITY B BP STANDARD(CRM STANDARD)
• AZAPROPAZONE IMPURITY STANDARD BP(CRM STANDARD)
• DuP-141
• AZAPROPAZONE ASSAY STANDARD BP(CRM STANDARD)
• AZAPROPAZONE IMPURITY C BP STANDARD(CRM STANDARD)
• AZAPROPAZONE IMPURITY STANDARD BP STANDARD(CRM STANDARD)
• AZAPROPAZONE IMPURITY A BP(CRM STANDARD)

Azapropazone

CAS: 13539-59-8

Azapropazone

Formula: C₁₆H₂₀N₄O₂H₂O

Purity: 99.8%

Color and Shape: Light Yellow To Light Green

Molecular weight: 318.16919

Ref: 47-534

Azapropazone

Controlled Product

CAS: 13539-59-8

Applications Azapropazone is a non-steroidal anti-inflammatory drug.
References Jones, C.: Curr. Med. res. Opin., 4, 3 (1976); In’t Veld, B., et al.;New Eng. J. Med., 345, 1515 (2001)

Formula: C₁₆H₂₀N₄O₂

Color and Shape: Light Yellow To Light Green

Molecular weight: 300.36

Ref: TR-A802400

Azapropazone-d7 Dihydrate

Controlled Product

CAS: 13539-59-8, 22304-30-9

Formula: C₁₆H₁₇D₇N₄O₄

Color and Shape: Neat

Molecular weight: 307.399

Ref: TR-A802402

Azapropazone

CAS: 13539-59-8

Azapropazone is a nonsteroidal anti-inflammatory drug that has been used to treat rheumatoid arthritis, osteoarthritis, and pain. It is also used as an adjunct therapy for the treatment of myocardial infarct. Azapropazone inhibits the synthesis of prostaglandins, leukotrienes, and thromboxanes by blocking cyclooxygenase enzymes. The inhibition of these enzymes by azapropazone may be due to its structural similarity to coumarin derivatives such as warfarin or dicumarol. Azapropazone has been shown to interact with other drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and may lead to gastrointestinal bleeding.

Formula: C₁₆H₂₀N₄O₂

Purity: Min. 95%

Molecular weight: 300.36 g/mol

Ref: 3D-NAA53959

Azapropazone

CAS: 13539-59-8

Azapropazone: Anti-inflammatory with uricosuric effect for rheumatoid arthritis and ankylosing spondylitis; lowers uric acid.

Formula: C₁₆H₂₀N₄O₂

Color and Shape: Solid

Molecular weight: 300.36

Ref: TM-T26710

Azapropazone

CAS: 13539-59-8

Color and Shape: Neat

Ref: 61-FOR0245.00

Azapropazone impurity standard

CAS: 13539-59-8

Azapropazone impurity standard

Color and Shape: White

Ref: 47-527