CAS 1354235-96-3

(1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Description:

The chemical substance known as (1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, with the CAS number 1354235-96-3, is a complex organic compound characterized by its multi-ring structure and various functional groups. This compound features a pyridoindole core, which is fused with a tetrahydro structure, contributing to its potential biological activity. The presence of a piperazine moiety suggests possible interactions with neurotransmitter systems, making it of interest in pharmacological research, particularly in the context of neuroactive compounds. The fluorophenyl and methoxyphenyl substituents may enhance lipophilicity and influence the compound's binding affinity to specific receptors. Additionally, the carboxylic acid functional group indicates potential for forming salts or esters, which can affect solubility and bioavailability. Overall, this compound's intricate structure and functional diversity position it as a candidate for further investigation in medicinal chemistry and drug development.

Formula: C₃₀H₃₁FN₄O₃

InChI: InChI=1S/C30H31FN4O3/c1-38-27-11-10-19(16-20(27)18-34-12-14-35(15-13-34)26-9-5-3-7-23(26)31)28-29-22(17-25(33-28)30(36)37)21-6-2-4-8-24(21)32-29/h2-11,16,25,28,32-33H,12-15,17-18H2,1H3,(H,36,37)/t25-,28+/m0/s1

InChI key: InChIKey=FUHCEERDBRGPQZ-LBNVMWSVSA-N

SMILES: C(O)(=O)[C@@H]1CC2=C([C@H](N1)C3=CC(CN4CCN(CC4)C5=C(F)C=CC=C5)=C(OC)C=C3)NC=6C2=CC=CC6

Synonyms:

• 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-[3-[[4-(2-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-, (1R,3S)-
• (1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
• (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
• trans-Ned 19

trans-Ned 19

CAS: 1354235-96-3

Formula: C₃₀H₃₁FN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 514.5905

Ref: IN-DA009FWY

trans-Ned 19

CAS: 1354235-96-3

Purity: ≥98%(HPLC)

Molecular weight: 514.601

Ref: 10-F979419

trans-Ned-19

Controlled Product

CAS: 1354235-96-3

Applications trans-Ned-19 is a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells.
References Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009); Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009); Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009);

Formula: C₃₀H₃₁FN₄O₃

Color and Shape: Yellow Solid

Molecular weight: 514.59

Ref: TR-N388750

trans-Ned 19

CAS: 1354235-96-3

trans-Ned 19 blocks NAADP and TPC, hindering calcium signaling and aorta relaxation at low histamine levels.

Formula: C₃₀H₃₁FN₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 514.59

Ref: TM-T12205L

Trans-Ned-19

CAS: 1354235-96-3

Formula: C₃₀H₃₁FN₄O₃

Molecular weight: 514.59

Ref: ST-EA-CP-A88100