CAS 135447-13-1

avidinorubicin

Description:

Avidinorubicin, with the CAS number 135447-13-1, is a synthetic anthracycline antibiotic that is primarily used in cancer therapy. It is a derivative of doxorubicin, designed to enhance its therapeutic efficacy while potentially reducing its cardiotoxicity. Avidinorubicin exhibits a mechanism of action that involves intercalation into DNA, thereby inhibiting topoisomerase II and disrupting the replication and transcription processes of cancer cells. This compound is characterized by its ability to induce apoptosis in malignant cells, making it effective against various types of tumors. Additionally, avidinorubicin is known for its solubility in organic solvents, which facilitates its formulation for intravenous administration. Its pharmacokinetics involve metabolism primarily in the liver, with excretion occurring through the biliary route. As with other anthracyclines, careful monitoring for side effects, including potential myelosuppression and gastrointestinal disturbances, is essential during treatment. Overall, avidinorubicin represents a significant advancement in the development of targeted cancer therapies.

Formula: C₆₀H₈₆N₄O₂₂

InChI: InChI=1/C60H86N4O22/c1-24-44(68)31(63(9)10)23-76-55(24)80-33-20-57(5,74)19-29-39(33)47(71)41-42(46(29)70)48(72)40-28(45(41)69)14-15-30-51(40)85-56-49(73)43(64(11)12)54(60(30,8)86-56)84-38-22-59(7,62)53(27(4)79-38)83-37-21-58(6,61)52(26(3)78-37)82-36-18-32(75-13)50(25(2)77-36)81-35(67)17-16-34(65)66/h14-15,24-27,31-33,36-38,43-44,49-50,52-56,68,70-71,73-74H,16-23,61-62H2,1-13H3,(H,65,66)

Synonyms:

• Avidinorubicin
• 2,6-Epoxy-2H-naphthaceno(1,2-b)oxocin-9,16-dione, 5-((O-4-O-(3-carboxy-1-oxopropyl)-2,6-dideoxy-3-O-methyl-alpha-L-lyxo-hexopyranosyl-(1-4)-O-3-amino-2,3,6-trideoxy-3-C-methyl-beta-L-ribo-hexopyranosyl-(1-4)-3-amino-2,3,6-trideoxy-3-C-methyl-beta-L-ribo-hexopyranosyl)oxy)-4-(dimethylamino)-3,4,5,6,11,12,13,14-octahydro-3,10,13,15-tetrahydroxy-6,13-dimethyl-11-((2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-

Avidinorubicin

CAS: 135447-13-1

Avidinorubicin is a novel anthracycline with platelet aggregation inhibitory activity.

Formula: C₆₀H₈₆N₄O₂₂

Color and Shape: Solid

Molecular weight: 1215.34

Ref: TM-T70898