CAS 13551-87-6

Misonidazole

Description:

Misonidazole is a chemical compound primarily recognized for its role as a radiosensitizer in cancer therapy. It is a nitroimidazole derivative, which means it contains a nitro group (-NO2) attached to an imidazole ring. This structure contributes to its biological activity, particularly in enhancing the effectiveness of radiation therapy against hypoxic tumor cells, which are often resistant to conventional treatments. Misonidazole is characterized by its relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. The compound exhibits a moderate toxicity profile, necessitating careful dosing in clinical applications. Additionally, it has been studied for its potential effects on various cellular processes, including DNA repair mechanisms. Misonidazole's chemical properties, such as its molecular weight and specific functional groups, play a crucial role in its interaction with biological systems, making it a subject of interest in both medicinal chemistry and oncology research.

Formula: C₇H₁₁N₃O₄

InChI: InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3

InChI key: InChIKey=OBBCSXFCDPPXOL-UHFFFAOYSA-N

SMILES: N(=O)(=O)C=1N(CC(COC)O)C=CN1

Synonyms:

• 1-(2-Hydroxy-3-methoxypropyl)-2-nitroimidazole
• 1-(2-Nitro-1-imidazolyl)-3-methoxy-2-propanol
• 1-Methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
• 2-Nitro-1H-imidazole-1-(3-methoxy-2-propanol)
• Imidazole-1-ethanol, α-(methoxymethyl)-2-nitro-
• Misonidazol
• Misonidazole
• Nsc 261037
• Racemic misonidazole
• Ro 7-0582
• Sr 1354
• Sri 1354
• α-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol
• Imidazole-1-ethanol, .alpha.- (methoxymethyl)-2-nitro-
• 1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
• 1H-Imidazole-1-ethanol, α-(methoxymethyl)-2-nitro-
• 13551-87-6
• .alpha.-(Methoxymethyl)-2-nitroimidazole-1-ethanol
• 1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)-2-propanol
• 1H-imidazole-1-ethanol, alpha-(methoxymethyl)-2-nitro-
• 1-Methoxy-3-(2-nitro-1-imidazolyl)-2-propanol

Misonidazole

CAS: 13551-87-6

Misonidazole

Purity: ≥95%

Molecular weight: 201.18g/mol

Ref: 54-BUP09812

Misonidazole

CAS: 13551-87-6

Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.

Formula: C₇H₁₁N₃O₄

Purity: 99.38%

Color and Shape: Solid

Molecular weight: 201.18

Ref: TM-T21899

Misonidazole

Controlled Product

CAS: 13551-87-6

Applications Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells
References Bonnet, M., et al.: Bioorg. Med. Chem., 22, 2123 (2014); Edwards, D.I.: Comprehensive Med. Chem., 2, 725 (1990); Murata, R., et al.: Radiother. Oncol., 87, 331 (2008); Brown, J.M. The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles. Int.J.Radiat.Oncol.Biol.Phys. 8(3-4), 675-682 (1982).

Formula: C₇H₁₁N₃O₄

Color and Shape: Yellow Solid

Molecular weight: 201.180

Ref: TR-M368700

Misonidazole

CAS: 13551-87-6

Misonidazole is a drug that is used to treat hyperproliferative disorders, such as cancer. It has been shown to be effective in the treatment of squamous cell carcinoma and other solid tumours. Misonidazole has minimal toxicity and is a covalent inhibitor of DNA synthesis. It also inhibits the growth of mice with tumors.

Formula: C₇H₁₁N₃O₄

Purity: Min. 95%

Molecular weight: 201.18 g/mol

Ref: 3D-NAA55187