CAS 135548-15-1

Oxeclosporin

Description:

Oxeclosporin, with the CAS number 135548-15-1, is a synthetic compound that belongs to the class of immunosuppressants, specifically a derivative of cyclosporine. It is primarily characterized by its ability to inhibit T-cell activation and proliferation, making it useful in the context of organ transplantation and autoimmune diseases. Oxeclosporin exhibits a unique mechanism of action by binding to specific intracellular proteins, which subsequently modulate the immune response. The compound is typically administered in a formulation that enhances its bioavailability and therapeutic efficacy. Its pharmacokinetic properties include a relatively long half-life, allowing for less frequent dosing compared to other immunosuppressants. Additionally, Oxeclosporin has been studied for its potential side effects, which may include nephrotoxicity and increased susceptibility to infections, common among immunosuppressive therapies. Overall, Oxeclosporin represents a significant advancement in the management of conditions requiring immune modulation, although careful monitoring is essential to mitigate adverse effects.

Formula: C₆₄H₁₁₅N₁₁O₁₄

InChI: InChI=1/C64H115N11O14/c1-24-26-27-42(15)54(78)53-58(82)66-44(25-2)59(83)69(17)34-50(77)70(18)46(30-36(3)4)57(81)68-51(40(11)12)63(87)71(19)47(31-37(5)6)56(80)65-43(16)55(79)67-45(35-89-29-28-76)60(84)72(20)48(32-38(7)8)61(85)73(21)49(33-39(9)10)62(86)74(22)52(41(13)14)64(88)75(53)23/h24,26,36-49,51-54,76,78H,25,27-35H2,1-23H3,(H,65,80)(H,66,82)(H,67,79)(H,68,81)/b26-24+/t42-,43+,44+,45-,46+,47+,48+,49+,51+,52+,53+,54-/m1/s1

Synonyms:

• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-12-[(2-hydroxyethoxy)methyl]-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,15,19,25,28-octamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• SDZ IMM 125

Oxeclosporin

CAS: 135548-15-1

Oxeclosporin is a hydroxyethyl derivative of serine(8)-cyclosporine; inhibits proliferation and functions of lymphocytes.

Formula: C₆₄H₁₁₅N₁₁O₁₄

Color and Shape: Solid

Molecular weight: 1262.66

Ref: TM-T70889