CAS 135558-11-1

Lobaplatin

Description:

Lobaplatin is a platinum-based chemotherapeutic agent, classified as a second-generation platinum compound. It is primarily used in the treatment of various cancers, including ovarian and lung cancers. Lobaplatin exhibits a unique mechanism of action, wherein it forms DNA cross-links, ultimately disrupting DNA replication and transcription, leading to apoptosis in cancer cells. This compound is characterized by its ability to overcome some forms of platinum resistance commonly seen with first-generation agents like cisplatin. Lobaplatin is generally administered intravenously and has been noted for its relatively lower toxicity profile compared to traditional platinum drugs, which can lead to fewer side effects such as nephrotoxicity and neurotoxicity. Its solubility and stability in physiological conditions also contribute to its effectiveness as a therapeutic agent. Ongoing research continues to explore its efficacy and potential combinations with other chemotherapeutic agents to enhance cancer treatment outcomes. As with all chemotherapeutics, careful monitoring of patient response and side effects is essential during treatment.

Formula: C₉H₁₈N₂O₃Pt

InChI: InChI=1/C6H14N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-6H,1-4,7-8H2;2H,1H3,(H,5,6);/q;-1;+2/p-1

SMILES: C1CC(CN)C1CN.CC(C(=O)O)[O-].[Pt]

Synonyms:

• Lobaplatin [INN]
• D 19466
• Lobaplatine
• Lobaplatine [INN-French]
• Lobaplatino
• Lobaplatino [INN-Spanish]
• Lobaplatinum
• Lobaplatinum [INN-Latin]
• Unii-Ox5Xk1Jd8C
• cis-(trans-1,2-Cyclobutanebis(methylamine))((S)-lactato-O(sup 1),O(sup 1))platinum
• Platinum, (1,2-cyclobutanedimethanamine-N,N')(2-hydroxypropanoato(2-)-O1,O2)-, (SP-4-3-(S),(trans))-
• Platinum, (rel-(1R,2R)-1,2-cyclobutanedimethanamine-kappaN,kappaN')((2S)-2-(hydroxy-kappa-O)propanoato(2-)-kappaO)-, (SP-4-3)-

Lobaplatin

CAS: 135558-11-1

Formula: C₉H₁₈N₂O₃Pt

Purity: %

Molecular weight: 397.3288

Ref: IN-DA009B4Q

Lobaplatin

CAS: 135558-11-1

Lobaplatin

Purity: ≥98%

Molecular weight: 397.33g/mol

Ref: 54-BUP01367

Lobaplatin

CAS: 135558-11-1

Formula: C₉H₂₀N₂O₃Pt

Molecular weight: 399.35

Ref: 7W-GP6290

Lobaplatin

CAS: 135558-11-1

Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe.

Formula: C₉H₁₈N₂O₃Pt

Purity: 98.00%

Color and Shape: Solid

Molecular weight: 397.33

Ref: TM-T15771