CAS 135575-42-7

Pneumocandin B0

Description:

Pneumocandin B0 is a lipopeptide compound that belongs to the class of echinocandins, which are known for their antifungal properties. It is produced by the fermentation of certain fungi, particularly species of Glarea lozoyensis. The structure of Pneumocandin B0 features a cyclic hexapeptide core linked to a long fatty acid chain, which contributes to its biological activity. This compound primarily acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of fungal cell walls, thereby exerting fungicidal effects against various pathogenic fungi, including Candida species. Pneumocandin B0 has been studied for its potential therapeutic applications, particularly in treating invasive fungal infections. Its solubility and stability characteristics make it suitable for formulation into pharmaceutical preparations. Additionally, it has a favorable safety profile, which is crucial for its use in clinical settings. Overall, Pneumocandin B0 represents an important compound in the development of antifungal therapies, particularly in the context of increasing resistance to conventional antifungal agents.

Formula: C₅₀H₈₀N₈O₁₇

InChI: InChI=1/C50H80N8O17/c1-5-25(2)20-26(3)12-10-8-6-7-9-11-13-37(66)52-31-22-35(64)46(71)56-48(73)41-33(62)18-19-57(41)50(75)39(34(63)23-36(51)65)54-47(72)40(43(68)42(67)28-14-16-29(60)17-15-28)55-45(70)32-21-30(61)24-58(32)49(74)38(27(4)59)53-44(31)69/h14-17,25-27,30-35,38-43,46,59-64,67-68,71H,5-13,18-24H2,1-4H3,(H2,51,65)(H,52,66)(H,53,69)(H,54,72)(H,55,70)(H,56,73)/t25?,26?,27-,30+,31-,32-,33-,34-,35+,38-,39-,40-,41-,42-,43-,46+/m0/s1

Synonyms:

• Pneumocardin B0
• pneumocandin B(0)
• N-{(2R,6S,9S,11R,12R,14aS,15S,20S,23S,25aS)-20-[(1S)-3-amino-1-hydroxy-3-oxopropyl]-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6-[(1S)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide

Pneumocandin B0

CAS: 135575-42-7

Formula: C₅₀H₈₀N₈O₁₇

Purity: 97%

Color and Shape: Solid

Molecular weight: 1065.2136

Ref: IN-DA007ZI8

Pneumocandin B0

CAS: 135575-42-7

Pneumocandin B0

Purity: 99%

Molecular weight: 1065.23g/mol

Ref: 54-OR1028737

Pneumocandin B0

CAS: 135575-42-7

Formula: C₅₀H₈₀N₈O₁₇

Color and Shape: White To Off-White Solid

Molecular weight: 1065.23

Ref: 4Z-P-169001

Pneumocandin B0

CAS: 135575-42-7

Pneumocandin B0

Purity: ≥95%

Molecular weight: 1065.21g/mol

Ref: 54-BUP13816

Pneumocandin B0

CAS: 135575-42-7

Formula: C₅₀H₈₀N₈O₁₇

Purity: >96.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 1,065.23

Ref: 3B-P2534

Pneumocandin B0

CAS: 135575-42-7

Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.

Formula: C₅₀H₈₀N₈O₁₇

Purity: 99.83% - ≥95%

Color and Shape: Solid

Molecular weight: 1065.21

Ref: TM-T5804

Pneumocandin B0

Controlled Product

CAS: 135575-42-7

Applications Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from several species of several different genera, such as Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.
References Schwartz, R., et al.: J. Antibiot., 45, 1853 (1992); Petersen, L., et al.: Appl. Microbiol. Biotechnol., 62, 263 (2003), Petersen, L., et al.: Appl. Microbiol. Biotechnol., 62, 263 (2003),

Formula: C₅₀H₈₀N₈O₁₇

Color and Shape: Neat

Molecular weight: 1065.21

Ref: TR-P645300

Pneumocandin B0

CAS: 135575-42-7

Pneumocandin B0 is a cyclic lipopeptide that exhibits in vitro antifungal activity against Candida spp. Pneumocandin B0 has been shown to bind to the cell wall of Candida albicans and other Candida spp. by interacting with chitin, leading to cell lysis. It also inhibits microbial growth by inhibiting protein synthesis, which is essential for cellular metabolism. Pneumocandin B0 has also been shown to have antimicrobial activity against a variety of bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA).
Pneumocandin B0 is an analog of pneumocandin A1, which differs from the latter by having a hydroxyl group instead of an amino group at the C3 position on the cyclic peptide backbone. This difference in chemical structure leads to different surface methodology and elution behavior in vitro assays.

Formula: C₅₀H₈₀N₈O₁₇

Purity: Min. 96 Area-%

Color and Shape: White Powder

Molecular weight: 1,065.21 g/mol

Ref: 3D-FP76367

Pneumocandin B0

CAS: 135575-42-7

Purity: 97%

Molecular weight: 1065.229

Ref: 10-F988193