CAS 135598-68-4

2''-cyano-2''-deoxy-1-β-D-arabinofuranosyl)cytosine

CAS: 135598-68-4

Ref: 7W-GN9881

2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine

CAS: 135598-68-4

2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine is an analog of the natural substrate for DNA cytosine methyltransferase, 5-methylcytosine. 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine inhibits the enzyme activity of DNA methyltransferase and blocks cell proliferation. It has been shown to be a potent antitumor agent in experimental models and may serve as a potential biomarker for cancer treatment. The drug is an oral prodrug that is activated by deamination in the liver and kidneys to release the active form, 5'-Azacytidine monophosphate (5'AZA). This metabolite then inhibits DNA methylation by binding to DNA cytosine methyltransferase, resulting in a loss of function of this enzyme.

Formula: C₁₀H₁₂N₄O₄

Purity: Min. 95%

Molecular weight: 252.23 g/mol

Ref: 3D-NC29827

CNDAC

CAS: 135598-68-4

CNDAC, a nucleoside analog, is a major metabolite of oral drug sapacitabine.

Formula: C₁₀H₁₂N₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 252.23

Ref: TM-T13621L