IRAK4 modulator-1, identified by its CAS number 1356014-97-5, is a small molecule inhibitor that targets the interleukin-1 receptor-associated kinase 4 (IRAK4), a key component in the signaling pathways of the immune response. This compound is primarily studied for its potential therapeutic applications in inflammatory diseases and certain cancers, as IRAK4 plays a crucial role in mediating pro-inflammatory signaling. The characteristics of IRAK4 modulator-1 include its ability to selectively inhibit IRAK4 activity, thereby disrupting downstream signaling cascades that lead to the production of inflammatory cytokines. This modulation can help in reducing excessive inflammation and may enhance the efficacy of other therapeutic agents. The compound's pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion (ADME), along with its safety profile, are critical for its development as a drug candidate. Ongoing research aims to further elucidate its mechanism of action and optimize its efficacy and safety for clinical use.

IRAK4 modulator-1

1356014-97-5: IRAK4 modulator-1, identified by its CAS number 1356014-97-5, is a small molecule inhibitor that targets the interleukin-1 receptor-associated kinase 4 (IRAK4), a key component in the signaling pathways of the immune response. This compound is primarily studied for its potential therapeutic applications in inflammatory diseases and certain cancers, as IRAK4 plays a crucial role in mediating pro-inflammatory signaling. The characteristics of IRAK4 modulator-1 include its ability to selectively inhibit IRAK4 activity, thereby disrupting downstream signaling cascades that lead to the production of inflammatory cytokines. This modulation can help in reducing excessive inflammation and may enhance the efficacy of other therapeutic agents. The compound's pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion (ADME), along with its safety profile, are critical for its development as a drug candidate. Ongoing research aims to further elucidate its mechanism of action and optimize its efficacy and safety for clinical use.

<p>N-(5-Chloro-2-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide</p>

N-(5-Chloro-2-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

<p>IRAK4 Modulator-1 (example 161), an IRAK4 modulator with an IC50 of 4.647 μM, is employed in the investigation of IRAK-mediated disorders [1].</p>

CAS 1356014-97-5

IRAK4 modulator-1

N-(5-Chloro-2-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Ref: 54-OR1065288

IRAK4 modulator-1

Ref: TM-T86740