CAS 1356084-46-2

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite

Description:

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite is a modified nucleoside used primarily in the field of oligonucleotide synthesis. This compound features several key characteristics that enhance its utility in biochemical applications. The presence of the tert-butyldimethylsilyl (TBDMS) group at the 2' position provides protection against hydrolysis, ensuring stability during synthesis and storage. The 5'-O-DMT (dimethoxytrityl) group serves as a protective moiety that facilitates the selective coupling of nucleotides during the synthesis process. The 1-methylguanosine base contributes to the compound's ability to form stable base pairs, which is crucial for the functionality of synthesized oligonucleotides. Additionally, the 3'-CE (cyanoethyl) phosphoramidite moiety allows for efficient incorporation into growing oligonucleotide chains. Overall, this compound is characterized by its stability, reactivity, and ability to enhance the efficiency of nucleic acid synthesis, making it valuable for research in molecular biology, genetics, and therapeutic applications.

Formula: C₄₇H₆₄N₇O₈PSi

Synonyms:

• Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite

CAS: 1356084-46-2

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite is a synthetic, antiviral monophosphate nucleoside. It is an activator that increases the activity of other nucleosides and can be used in DNA synthesis by incorporation into DNA molecules. 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-1-methylguanosine 3'-CE phosphoramidite has been shown to be effective against Hepatitis C virus, Human Immunodeficiency Virus 1 (HIV), and Herpes Simplex Virus 1.

Formula: C₄₇H₆₄N₇O₈PSi

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 914.11 g/mol

Ref: 3D-NB139125