CAS 1356383-38-4

Captopril-d3

Description:

Captopril-d3 is a deuterated form of captopril, which is an angiotensin-converting enzyme (ACE) inhibitor primarily used in the treatment of hypertension and heart failure. The deuteration (indicated by the "d3" in its name) involves the substitution of three hydrogen atoms with deuterium, a stable isotope of hydrogen. This modification can enhance the compound's stability and alter its pharmacokinetic properties, making it useful in research applications, particularly in metabolic studies and drug metabolism investigations. Captopril-d3 retains the core structure and mechanism of action of captopril, which includes the inhibition of ACE, leading to decreased production of angiotensin II and subsequent vasodilation. The compound is typically characterized by its molecular formula, which reflects the presence of deuterium, and its physical properties may differ slightly from those of non-deuterated captopril. As with other ACE inhibitors, it may exhibit side effects such as cough or hypotension, but the specific effects of the deuterated version may vary and warrant further investigation.

Formula: C₉H₁₅NO₃S

InChI: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1/i4D2,7D

InChI key: InChIKey=FAKRSMQSSFJEIM-SIHDFBQLSA-N

SMILES: C([C@@H](CS)C)(=O)N1[C@](C(O)=O)(CCC1([2H])[2H])[2H]

Synonyms:

• Captopril-d3
• SQ-14225-d3
• [2H3]-Captopril
• (-)-Captopril-d3 (L-proline-2,5,5-d3)
• (2S)-1-(3-Marcapto-2-Methyl-1-oxopionyl]-L-proline-2,5,5-d3

Captopril-d3

CAS: 1356383-38-4

Formula: C₉H₁₂D₃NO₃S

Color and Shape: White To Off-White Solid

Molecular weight: 220.30

Ref: 4Z-C-173

Captopril-d3

Controlled Product

CAS: 1356383-38-4

Applications Orally active angiotensin-converting enzyme (ACE) inhibitor.
References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),

Formula: C₉D₃H₁₂NO₃S

Color and Shape: White Solid

Molecular weight: 220.30

Ref: TR-C175752