CAS 1356390-47-0

Hepcidin 25 (human)

Description:

Hepcidin 25 is a peptide hormone primarily produced by the liver, playing a crucial role in iron homeostasis in the human body. It is composed of 25 amino acids and is part of the larger hepcidin family, which regulates iron absorption and distribution. The primary function of Hepcidin 25 is to inhibit iron transport by binding to the iron exporter ferroportin, leading to its internalization and degradation, thereby reducing iron release from macrophages and intestinal cells into the bloodstream. This regulation is vital for maintaining appropriate iron levels and preventing conditions such as anemia or iron overload. Hepcidin levels can be influenced by various factors, including inflammation, hypoxia, and iron status, making it an important biomarker for various diseases, including anemia of chronic disease and hereditary hemochromatosis. The CAS number 1356390-47-0 uniquely identifies this specific peptide, facilitating its study and application in research and clinical settings.

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉

Synonyms:

• Hepcidin-25 (human) (H-5926.0500)

Hepcidin-25 (human)

CAS: 1356390-47-0

Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans. Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux. Nemeth et al. demonstrated that the N-terminal part of the peptide hormone is essential for its activity. Former CAS-number 342790-21-0.

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉

Purity: 95.0%

Color and Shape: White Powder

Molecular weight: 2789.4

Ref: 01-4040671

Hepcidin 25 (human)

CAS: 1356390-47-0

Hepcidin 25 (human)

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉

Color and Shape: Solid

Molecular weight: 2,789.35g/mol

Ref: 54-BIBA1031

Hepcidin-25 (Human)

CAS: 1356390-47-0

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉

Molecular weight: 2789.37

Ref: 4Z-PH-025001

Hepcidin-25 (human) trifluoroacetate salt

CAS: 1356390-47-0

Please enquire for more information about Hepcidin-25 (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₁₃H₁₇₀N₃₄O₃₁S₉·C₂HF₃O₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 2,903.38 g/mol

Ref: 3D-FH109655