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CAS 135649-01-3

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Methoxy polyethylene glycol succinimidyl carbonate

Description:
Methoxy polyethylene glycol succinimidyl carbonate (MPEG-SC) is a bioconjugation reagent commonly used in the field of biochemistry and pharmaceutical development. It features a methoxy polyethylene glycol (MPEG) moiety, which enhances solubility and biocompatibility, making it suitable for various applications, including drug delivery and protein modification. The succinimidyl carbonate group allows for the formation of stable amide bonds with primary amines, facilitating the conjugation of MPEG to proteins, peptides, or other biomolecules. This compound is typically characterized by its ability to improve the pharmacokinetic properties of conjugated drugs, such as increased circulation time and reduced immunogenicity. MPEG-SC is generally soluble in polar solvents, and its reactivity can be influenced by factors such as pH and temperature. Safety considerations include handling it in a well-ventilated area and using appropriate personal protective equipment, as with many chemical reagents. Overall, MPEG-SC is a valuable tool in the development of therapeutic agents and biomaterials.
Formula:(C2H4O)nC6H7NO5
Synonyms:
  • α-Methoxy-ω-(carbonyloxysuccinimidyl)polyethylene glycol
  • Poly(oxy-1,2-ethanediyl), α-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-ω-methoxy-
  • Sunbright ME 200TS
  • Methyl polyethylene glycol carbonate N-hydroxysuccinimide ester
  • O-(N-Succinimidyloxycarbonyl)-O′-methylpolyethylene glycol
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