CAS 1356933-70-4

RAMIPRILAT-D3

Description:

Ramiprilat-D3, identified by the CAS number 1356933-70-4, is a deuterated form of ramiprilat, which is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor ramipril. This compound is characterized by its role in the treatment of hypertension and heart failure, functioning by inhibiting the conversion of angiotensin I to angiotensin II, thereby leading to vasodilation and reduced blood pressure. The incorporation of deuterium in Ramiprilat-D3 can enhance its pharmacokinetic properties, potentially improving stability and metabolic profiles. Typically, ramiprilat exhibits high solubility in water and is administered orally. Its mechanism of action involves the modulation of the renin-angiotensin system, which is crucial in regulating blood pressure and fluid balance. As with other ACE inhibitors, common side effects may include cough, elevated potassium levels, and hypotension. The deuterated version may also be used in research settings to study drug metabolism and pharmacodynamics more precisely.

Formula: C₂₁H₂₅D₃N₂O₅

Synonyms:

• Ramipril Diacid-d3
• HOE 498 Diacid-d3
• RAMIPRILAT-D3
• (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl-d3]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid

Ramiprilat-d3 ~90%(Mixture of Diastereomers)

Controlled Product

CAS: 1356933-70-4

Applications A labelled metabolite of Ramipril (R111000).
References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),

Formula: C₂₁₂H₃H₂₅N₂O₅

Color and Shape: Neat

Molecular weight: 391.48

Ref: TR-R111006

Ramiprilat-d3(Mixture of Diastereomers)

Controlled Product

CAS: 1356933-70-4

Applications A labelled metabolite of Ramipril (R111000).
References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),

Formula: C₂₁₂H₃H₂₅N₂O₅

Color and Shape: Neat

Molecular weight: 391.48

Ref: TR-R111011