CAS 1356962-20-3

AZD-3463

Description:

AZD-3463 is a small molecule inhibitor primarily targeting the phosphoinositide 3-kinase (PI3K) pathway, which is crucial in various cellular processes, including growth, proliferation, and survival. It has been investigated for its potential therapeutic applications in oncology, particularly in cancers with mutations in the PI3K pathway. The compound exhibits selectivity for specific PI3K isoforms, which may contribute to its efficacy and reduced side effects compared to broader-spectrum inhibitors. AZD-3463 is characterized by its ability to inhibit tumor cell growth and induce apoptosis in cancer cells, making it a candidate for targeted cancer therapies. Its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are essential for determining its clinical utility. Ongoing research aims to elucidate its effectiveness in combination with other treatments and to better understand its safety profile in various patient populations. As with many investigational drugs, further studies are necessary to fully establish its therapeutic potential and optimize its use in clinical settings.

Synonyms:

• AZD 3463
• N-[4-(4-Amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine
• 2-Pyrimidinamine, N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-

ALK/IGF1R inhibitor

CAS: 1356962-20-3

Formula: C₂₄H₂₅ClN₆O

Purity: 99%

Color and Shape: Solid

Molecular weight: 448.9479

Ref: IN-DA009C96

AZD-3463

CAS: 1356962-20-3

AZD-3463

Purity: ≥98%

Molecular weight: 448.95g/mol

Ref: 54-BUP06426

AZD-3463

CAS: 1356962-20-3

AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.

Formula: C₂₄H₂₅ClN₆O

Purity: 99.13%

Color and Shape: Solid

Molecular weight: 448.95

Ref: TM-T1967

AZD3463

Controlled Product

CAS: 1356962-20-3

Formula: C₂₄H₂₅ClN₆O

Color and Shape: Neat

Molecular weight: 448.948

Ref: TR-A808105

AZD3463

CAS: 1356962-20-3

AZD3463 is a small molecule that inhibits the ubiquitin proteasome. It has been shown to be effective in vivo, as well as in vitro, for the treatment of cancer. AZD3463 binds to the carbonyl group on the protein substrate and inhibits the activity of the drug-metabolizing enzyme, adp-ribose hydrolase. This inhibition prevents degradative processes from occurring within cells and leads to an increase in autophagy. AZD3463 also inhibits epidermal growth factor receptor (EGFR) signaling pathways and activates tumor suppressor genes such as p53 and p21. Pharmacokinetic properties have been studied in mice, rats, and cynomolgus monkeys.

Formula: C₂₄H₂₅ClN₆O

Purity: Min. 95%

Molecular weight: 448.95 g/mol

Ref: 3D-GEC96220