CAS 135729-55-4

2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (1:1)

Description:

2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-1-one hydrochloride is a chemical compound characterized by its complex bicyclic structure, which includes a nitrogen-containing bicyclic moiety and a tetrahydroisoquinoline framework. This compound is typically classified as a tertiary amine due to the presence of the azabicyclo structure. It exhibits properties associated with both central nervous system activity and potential therapeutic applications, particularly in the realm of neuropharmacology. The hydrochloride salt form indicates that it is a hydrochloride salt, which enhances its solubility in water and stability for pharmaceutical formulations. The stereochemistry of the compound, particularly the (3S) configuration, suggests specific spatial arrangements that may influence its biological activity and receptor interactions. Overall, this compound's unique structural features and properties make it a subject of interest in medicinal chemistry and drug development.

Formula: C₁₉H₂₃ClN₂O

InChI: InChI=1/C19H22N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,11,13,17H,1,3,5,7-10,12H2;1H/t17-;/m1./s1

SMILES: C1Cc2cccc3c2c(C1)cn([C@@H]1CN2CCC1CC2)c3=O.Cl

Synonyms:

• (S)-N-(1-Azabicyclo(2.2.2)oct-3-yl)-2,4,5,6-tetrahydro-1H-benzo(de)isoquinolin-1-one hydrochloride

PALONOSETRON IMPURITY MIXTURE CRS

CAS: 135729-55-4, 135729-75-8

PALONOSETRON IMPURITY MIXTURE CRS

Ref: 41-Y0002520

Palonosetron Related Compound E (2-[(3S)-Quinuclidin-3-yl]-2,4,5,6-tetrahydro-1H-benzo[de]isoquinolin-1-one hydrochloride)

CAS: 135729-55-4

Lactams, nesoi

Formula: C₁₉H₂₂N₂O·HCl

Color and Shape: Yellow Solid

Molecular weight: 330.14989

Ref: 45-1492266

RS 42358-197

CAS: 135729-55-4

RS 42358-197

Purity: ≥98%

Molecular weight: 330.85g/mol

Ref: 54-BUP07139

Palonosetron EP Impurity D HCl (Palonosetron USP Related Compound E)

CAS: 135729-55-4

Formula: C₁₉H₂₂N₂O·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 294.40 36.46

Ref: 4Z-P-539

Palonosetron-3-ene Hydrochloride

Controlled Product

CAS: 135729-55-4

Impurity Palonosetron Related Compound E USP
Applications Palonosetron-3-ene Hydrochloride is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)

Formula: C₁₉H₂₂N₂O·ClH

Color and Shape: Off-White To Yellow

Molecular weight: 330.85

Ref: TR-P165825

Palonosetron USP Related Compound E

CAS: 135729-55-4

Formula: C₁₉H₂₂N₂OHCl

Molecular weight: 294.4 : 36.5

Ref: ST-EA-CP-P14004

RS 42358-197

CAS: 135729-55-4

RS 42358-197 (RS 25259-007) is a competitive 5-HT3 receptor antagonist.

Formula: C₁₉H₂₃ClN₂O

Purity: 99.70%

Color and Shape: Solid

Molecular weight: 330.85

Ref: TM-T20739