CAS 135729-61-2: Palonosetron
Description:Palonosetron is a selective serotonin 5-HT3 receptor antagonist primarily used as an antiemetic to prevent nausea and vomiting associated with chemotherapy and surgery. It is characterized by its high affinity for the 5-HT3 receptor, which allows it to effectively block the action of serotonin, a neurotransmitter involved in triggering nausea. Palonosetron has a longer half-life compared to other 5-HT3 antagonists, enabling it to provide prolonged antiemetic effects with a single dose. The substance is typically administered intravenously or orally and is known for its favorable safety profile, with fewer side effects such as sedation or constipation compared to other antiemetics. Its chemical structure includes a bicyclic core, contributing to its unique pharmacological properties. Palonosetron is marketed under various brand names and is an important option in the management of chemotherapy-induced nausea and vomiting, particularly in patients receiving highly emetogenic chemotherapy regimens.
Formula:C19H24N2O
InChI:InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1
InChI key:InChIKey=CPZBLNMUGSZIPR-NVXWUHKLSA-N
SMILES:O=C1C2=CC=CC3=C2C(CN1C4CN5CCC4CC5)CCC3
- Synonyms:
- (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
- (S-(R*,R*))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
- 1H-Benz(de)isoquinolin-1-one, 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-, (S-(R*,R*))-
- 1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aS)-
- 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
- 2-Qhbiqo
- Palonosetron [INN]
- Rs 25233-197
- Rs 25259-197
- Rs 25259-198
- See more synonyms
- Rs-25233-198
- (-)-Palonosetron
- Palonosetron
Brand | Product data | Purity | Price range | Estimated delivery |
---|---|---|---|---|
![]() | Palonosetron Hydrochloride REF: 3B-P2051CAS: | >98.0%(T)(HPLC) | 84.00 €~291.00 € | Tue 18 Mar 25 |
![]() | Palonosetron REF: IN-DA009CE3CAS: 135729-61-2 | 98% | To inquire | Tue 25 Mar 25 |
![]() | Palonosetron REF: 4Z-P-5344CAS: 135729-61-2 | - - - | To inquire | Tue 01 Apr 25 |
![]() | Palonosetron REF: TM-T22393CAS: 135729-61-2 | 98% | 908.00 €~2,375.00 € | Tue 13 May 25 |
![]() | Palonosetron REF: TR-P165830CAS: 135729-61-2 | - - - | - - - | Discontinued product |
![]() | Palonosetron REF: 3D-FP43808CAS: 135729-61-2 | Min. 95% | - - - | Discontinued product |

Palonosetron Hydrochloride
Ref: 3B-P2051
1g | 291.00 € | ||
200mg | 84.00 € |

Ref: IN-DA009CE3
5mg | 148.00 € | ||
10mg | 154.00 € | ||
25mg | 336.00 € | ||
100mg | To inquire |

Ref: 4Z-P-5344
5mg | To inquire | ||
10mg | To inquire | ||
25mg | To inquire | ||
50mg | To inquire | ||
100mg | To inquire |

Palonosetron
Ref: TM-T22393
25mg | 1,444.00 € | ||
50mg | 1,882.00 € | ||
100mg | 2,375.00 € |

Palonosetron
Controlled ProductRef: TR-P165830
1g | Discontinued | Request information | |
100mg | Discontinued | Request information |

Ref: 3D-FP43808
10mg | Discontinued | Request information | |
25mg | Discontinued | Request information | |
50mg | Discontinued | Request information |