CAS 135729-61-2

Palonosetron

Description:

Palonosetron is a selective serotonin 5-HT3 receptor antagonist primarily used as an antiemetic to prevent nausea and vomiting associated with chemotherapy and surgery. It is characterized by its high affinity for the 5-HT3 receptor, which allows it to effectively block the action of serotonin, a neurotransmitter involved in triggering nausea. Palonosetron has a longer half-life compared to other 5-HT3 antagonists, enabling it to provide prolonged antiemetic effects with a single dose. The substance is typically administered intravenously or orally and is known for its favorable safety profile, with fewer side effects such as sedation or constipation compared to other antiemetics. Its chemical structure includes a bicyclic core, contributing to its unique pharmacological properties. Palonosetron is marketed under various brand names and is an important option in the management of chemotherapy-induced nausea and vomiting, particularly in patients receiving highly emetogenic chemotherapy regimens.

Formula: C₁₉H₂₄N₂O

InChI: InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1

InChI key: InChIKey=CPZBLNMUGSZIPR-NVXWUHKLSA-N

SMILES: O=C1C2=C3[C@@](CN1[C@H]4C5CCN(C4)CC5)(CCCC3=CC=C2)[H]

Synonyms:

• (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
• (S-(R*,R*))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
• 1H-Benz(de)isoquinolin-1-one, 2-(1-azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-, (S-(R*,R*))-
• 1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, (3aS)-
• 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
• 2-Qhbiqo
• Palonosetron [INN]
• Rs 25233-197
• Rs 25259-197
• Rs 25259-198
• Rs-25233-198
• (-)-Palonosetron

Palonosetron Hydrochloride

CAS: 135729-61-2, 135729-62-3

Formula: C₁₉H₂₄N₂O·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 332.87

Ref: 3B-P2051

Palonosetron

CAS: 135729-61-2

Formula: C₁₉H₂₄N₂O

Purity: 98%

Molecular weight: 296.4067

Ref: IN-DA009CE3

Palonosetron

CAS: 135729-61-2

Formula: C₁₉H₂₄N₂O

Molecular weight: 296.41

Ref: 4Z-P-5344

Palonosetron

CAS: 135729-61-2

Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

Formula: C₁₉H₂₄N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 296.41

Ref: TM-T22393