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CAS 135729-62-3

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Palonosetron Hydrochloride

Description:
Palonosetron hydrochloride is a selective serotonin 5-HT3 receptor antagonist primarily used as an antiemetic to prevent nausea and vomiting associated with chemotherapy and surgery. It is characterized by its high affinity for the 5-HT3 receptor, which allows it to effectively block the action of serotonin, a neurotransmitter involved in the vomiting reflex. The substance is typically administered intravenously or orally, and it has a longer half-life compared to other 5-HT3 antagonists, allowing for less frequent dosing. Palonosetron hydrochloride is known for its efficacy in both acute and delayed nausea and vomiting, making it a valuable option in clinical settings. Its chemical structure includes a bicyclic core, contributing to its pharmacological properties. Additionally, it is generally well-tolerated, with a side effect profile that may include headache, constipation, and dizziness. As with any medication, it is important to consider contraindications and potential interactions with other drugs when prescribing palonosetron hydrochloride.
Formula:C19H24N2O·ClH
InChI:InChI=1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1
InChI key:InChIKey=OLDRWYVIKMSFFB-SSPJITILSA-N
SMILES:O=C1C2=C3[C@@](CN1[C@H]4C5CCN(C4)CC5)(CCCC3=CC=C2)[H].Cl
Synonyms:
  • (3aR)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (1:1)
  • (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride
  • (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride
  • (3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride
  • (S,S)-Palonosetron Hydrochloride
  • 1H-Benz[de]isoquinolin-1-one, 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-, monohydrochloride, [S-(R*,R*)]-
  • 1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, monohydrochloride, (3aS)-
  • 1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, hydrochloride (1:1), (3aS)-
  • Aloxi
  • Onicit
  • See more synonyms
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