CAS 135729-78-1

N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl] 5,6,7,8-tetrahydronaphthalene-1-carboxamide

Description:

N-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl] 5,6,7,8-tetrahydronaphthalene-1-carboxamide, with CAS number 135729-78-1, is a chemical compound characterized by its complex bicyclic structure and amide functional group. This compound features a bicyclic azabicyclo[2.2.2]octane moiety, which contributes to its unique three-dimensional conformation, potentially influencing its biological activity and interaction with receptors. The presence of the tetrahydronaphthalene ring system adds to its hydrophobic character, which may affect solubility and permeability in biological systems. The amide group is known for its ability to form hydrogen bonds, which can enhance the compound's stability and reactivity. This substance may exhibit pharmacological properties, making it of interest in medicinal chemistry, particularly in the development of drugs targeting specific biological pathways. Its stereochemistry, indicated by the (3S) designation, suggests that it may have specific interactions with biological targets, which is crucial for its potential therapeutic applications. Overall, this compound's structural features suggest a complex interplay of physical and chemical properties that could be leveraged in drug design.

Formula: C₁₈H₂₄N₂O

InChI: InChI=1S/C18H24N2O/c21-18(19-17-12-20-10-8-14(17)9-11-20)16-7-3-5-13-4-1-2-6-15(13)16/h3,5,7,14,17H,1-2,4,6,8-12H2,(H,19,21)/t17-/m1/s1

InChI key: InChIKey=UKUDKGCYXPIZRH-QGZVFWFLSA-N

SMILES: C(N[C@H]1C2(CCN(C1)CC2)[H])(=O)C3=C4C(=CC=C3)CCCC4

Synonyms:

• (S)-N-(1-Azabicyclo[2.2.2]Oct-3-Yl)-5,6,7,8-Tetrahydro-1-Naphthalenecarboxamide
• (S)-N-(quinuclidin-3-yl)-5,6,7,8- tetrahydronaphthalene-1-carboxamide
• (S)-N-1-azabicyclo[2.2.0]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide
• 1-Naphthalenecarboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-
• 1-Naphthalenecarboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-, (S)-
• N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-1-naphthalenecarboxamide
• N-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-5,6,7,8-tetrahydronaphthalene-1-carboxamide

1-Naphthalenecarboxamide,N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6,7,8-tetrahydro-

CAS: 135729-78-1

Formula: C₁₈H₂₄N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 284.3960

Ref: IN-DA007NJF

(S)-N-(quinuclidin-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide

CAS: 135729-78-1

(S)-N-(quinuclidin-3-yl)-5,6,7,8-tetrahydronaphthalene-1-carboxamide

Purity: 98%

Ref: 54-OR1039840

Palonosetron Impurity 3

CAS: 135729-78-1

Formula: C₁₈H₂₄N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 284.40

Ref: 4Z-P-5311

(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide

Controlled Product

CAS: 135729-78-1

Applications (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide is an impurity in the synthesis of Palonosetron HCl (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

Formula: C₁₈H₂₄N₂O

Color and Shape: Neat

Molecular weight: 284.40

Ref: TR-A795320

(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide

CAS: 135729-78-1

Please enquire for more information about (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₈H₂₄N₂O

Purity: Min. 95%

Molecular weight: 284.4 g/mol

Ref: 3D-KFA72978

Palonosetron Impurity 3

CAS: 135729-78-1

Formula: C₁₈H₂₄N₂O

Molecular weight: 284.40

Ref: ST-EA-CP-P14010