CAS 1357349-91-7

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Description:

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, with the CAS number 1357349-91-7, is a synthetic organic compound characterized by its complex heterocyclic structure. This compound features a pyrazolo[3,4-d]pyrimidine core, which is a bicyclic structure containing both pyrazole and pyrimidine rings. The presence of a 1-(1-methylethyl) group indicates a branched alkyl substituent, contributing to its hydrophobic characteristics. Additionally, the 2-phenylethynyl substituent introduces an aromatic component, enhancing its potential for interactions in biological systems. The compound is likely to exhibit specific biological activities, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. Its unique structure may influence its solubility, stability, and reactivity, which are critical factors in drug design and efficacy. Overall, this compound represents a class of molecules that may have applications in various fields, including biochemistry and pharmacology, due to its structural diversity and potential biological relevance.

Formula: C₁₆H₁₅N₅

Synonyms:

• SPP86 >=98% (HPLC)
• 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-
• 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• SPP 86

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS: 1357349-91-7

Formula: C₁₆H₁₅N₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 277.3238

Ref: IN-DA01ENM0

SPP-86

CAS: 1357349-91-7

SPP-86

Purity: ≥98%

Molecular weight: 277.32g/mol

Ref: 54-BUP09376

SPP-86

CAS: 1357349-91-7

SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.

Formula: C₁₆H₁₅N₅

Purity: 99.53%

Color and Shape: Solid

Molecular weight: 277.32

Ref: TM-T16923

SPP86

CAS: 1357349-91-7

SPP86 is a synthetic small molecule that inhibits the process of autophagy. It is a potent inhibitor of the mammalian target of rapamycin (mTOR) and inhibits cancer cell growth in vitro and in vivo. SPP86 also enhances the effects of other anticancer drugs, such as hydrogen sulfate, which is used to treat intrahepatic cholangiocarcinoma. The mechanism of action of SPP86 may be due to its ability to inhibit kinase receptors, including EGFR mutant proteins, as well as its function as a neurotrophic factor. This drug has been shown to be effective in animal models for breast cancer resistant to EGFR inhibitors.

Formula: C₁₆H₁₅N₅

Purity: Min. 95%

Molecular weight: 277.32 g/mol

Ref: 3D-HEC34991