CAS 135819-69-1

palmitoyl rhizoxin

Description:

Palmitoyl rhizoxin is a synthetic derivative of rhizoxin, a natural product originally isolated from the fungus Rhizopus chinensis. This compound is characterized by its palmitoyl group, which enhances its lipophilicity, potentially improving its bioavailability and cellular uptake. Rhizoxin itself is known for its potent antitumor activity, primarily through its ability to inhibit microtubule dynamics, thereby disrupting mitotic spindle formation and leading to cell cycle arrest. Palmitoyl rhizoxin retains these biological properties while also exhibiting enhanced stability and solubility in lipid environments. The compound is of interest in medicinal chemistry and cancer research due to its mechanism of action and potential therapeutic applications. Additionally, its structural modifications may allow for the development of more effective analogs with improved pharmacokinetic profiles. As with many bioactive compounds, further studies are necessary to fully elucidate its pharmacological effects, toxicity, and potential clinical applications.

Formula: C₅₁H₇₇NO₁₀

InChI: InChI=1/C51H77NO10/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-25-46(53)61-45-32-42(37(5)48(56-8)36(4)24-22-23-34(2)28-40-33-57-38(6)52-40)60-50(55)49-43(59-49)30-39-29-41(58-47(54)31-39)35(3)26-27-44-51(45,7)62-44/h22-24,26-28,33,35,37,39,41-45,48-49H,9-21,25,29-32H2,1-8H3/b23-22+,27-26+,34-28+,36-24+

Synonyms:

• RS-1541
• Palmitoyl rhizoxin
• RS 1541
• Rhizoxin, 13-hexadecanoate
• 8-[(3E,5E,7E)-2-methoxy-1,3,7-trimethyl-8-(2-methyl-1,3-oxazol-4-yl)octa-3,5,7-trien-1-yl]-11,16-dimethyl-6,19-dioxo-4,7,12,18-tetraoxatetracyclo[15.3.1.03,5.011,13]henicos-14-en-10-yl hexadecanoate

Palmitoyl rhizoxin

CAS: 135819-69-1

Palmitoyl rhizoxin is a highly lipophilic antitumor compound that acts by inhibiting tubulin polymerization and has stronger in vivo activity than rhizoxin.

Formula: C₅₁H₇₇NO₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 864.174

Ref: TM-T25917