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CAS 135821-54-4

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Ceftizoxime alapivoxil

Description:
Ceftizoxime alapivoxil is a prodrug of the cephalosporin antibiotic ceftizoxime, designed to enhance oral bioavailability. It is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a range of Gram-positive and Gram-negative bacteria. The compound is typically administered to treat various infections, including respiratory tract infections, urinary tract infections, and skin infections. Ceftizoxime alapivoxil is known for its stability in the presence of beta-lactamases, enzymes produced by some bacteria that confer resistance to beta-lactam antibiotics. The prodrug nature of ceftizoxime alapivoxil allows for improved absorption and conversion to the active form in the body, which is crucial for its therapeutic efficacy. Its pharmacokinetic profile includes a relatively short half-life, necessitating multiple doses for sustained antibacterial activity. As with many antibiotics, potential side effects may include gastrointestinal disturbances and allergic reactions. Overall, ceftizoxime alapivoxil represents a significant advancement in the development of cephalosporin antibiotics for effective oral treatment of bacterial infections.
Formula:C22H28N6O8S2
InChI:InChI=1/C22H28N6O8S2/c1-10(23)15(29)26-21-24-11(8-38-21)13(27-34-5)16(30)25-14-17(31)28-12(6-7-37-18(14)28)19(32)35-9-36-20(33)22(2,3)4/h6,8,10,14,18H,7,9,23H2,1-5H3,(H,25,30)(H,24,26,29)/b27-13-/t10-,14+,18+/m0/s1
Synonyms:
  • [(2,2-dimethylpropanoyl)oxy]methyl (6R,7R)-7-{[(2Z)-2-[2-(L-alanylamino)-1,3-thiazol-4-yl]-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • Ceftizoxime alapivoxil
  • (Pivaloyloxy)methyl 7-((Z)-2-(2-((S)-2-aminopropanamido)thiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 7-[[2-[2-[(2-amino-1-oxopropyl)amino]-4-thiazolyl]-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester
  • Ceftizoxime alapivoxil USP/EP/BP
  • Ceftizoxime Alapivoxil Hydrochloride
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-[2-[[(2S)-2-amino-1-oxopropyl]amino]-4-thiazolyl]-2-(methoxyimino)acetyl]amino]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)-
  • 7-[[(2z)-[2-[[(2s)-2-amino-1-oxopropyl]amino]-4-thiazolyl](methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester
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Found 2 products.
  • Ceftizoxime Alapivoxil
    TRC
    + Info

    Ceftizoxime Alapivoxil

    Controlled Product
    CAS:
    Formula:C22H28N6O8S2
    Color and Shape:Neat
    Molecular weight:568.623

    Ref: TR-C243905

    250mg
    8,684.00€
  • Ceftizoxime alapivoxil
    Biosynth
    + Info

    Ceftizoxime alapivoxil

    CAS:
    <p>Ceftizoxime alapivoxil is a prodrug antibiotic, which is derived from ceftizoxime, a third-generation cephalosporin. This semi-synthetic source enables the compound to effectively combat a wide range of bacterial infections by improving oral bioavailability compared to its parent compound. Once administered, ceftizoxime alapivoxil is metabolized in the body to release ceftizoxime, which exerts its antibacterial activity by binding to penicillin-binding proteins (PBPs) on bacterial cell walls. This binding action inhibits the transpeptidation step critical for cell wall synthesis, leading to cell lysis and bacterial death.</p>
    Purity:Min. 95%

    Ref: 3D-FC41150

    1mg
    303.00€
    5mg
    537.00€
    10mg
    814.00€