CAS 1359873-45-2

6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine Hydrochloride

Controlled Product

CAS: 1359873-45-2

Applications 6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]thieno[2,3-d]pyrimidine is an inhibitor of fusion protein interaction of menin-mixed lineage leukemia (menin-MLL). Menin-MLL inhibitors downregulate the expression of target genes required for MLL fusion protein oncogenic activity and thus effectively reverse MLL fusion protein-mediated leukemic transformation.
References Grembecka, J. et al.: Nat. Chem. Biol., 8, 277 (2012);

Formula: C₁₄H₁₇ClN₆S₂

Color and Shape: Neat

Molecular weight: 368.91

Ref: TR-E926745