CAS 136033-70-0

DERMASEPTIN

Description:

Dermaseptin is a peptide derived from the skin secretions of certain amphibians, particularly from the genus Phyllomedusa. It exhibits antimicrobial properties, making it of interest in pharmaceutical and biomedical research. The structure of Dermaseptin consists of a sequence of amino acids that contribute to its ability to disrupt microbial membranes, leading to its effectiveness against a range of bacteria, fungi, and some viruses. Its mechanism of action typically involves the formation of pores in the microbial cell membrane, resulting in cell lysis. Dermaseptin is also noted for its low toxicity to mammalian cells, which enhances its potential as a therapeutic agent. Additionally, research into Dermaseptin has explored its applications in wound healing and as a preservative in cosmetic formulations due to its antimicrobial efficacy. Overall, Dermaseptin represents a promising candidate in the search for new antimicrobial agents, particularly in an era of increasing antibiotic resistance.

Formula: C₁₅₂H₂₅₇N₄₃O₄₄S₂

Synonyms:

• Dermaseptin I
• Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln
• Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Met-Ala-Leu-His-Ala-Gly-Lys-Ala-Leu-Gly-Ala-Ala-Ala-Ala-Asp-Thr-Ile-Ser-Gln-Gly-Thr-Gln

Dermaseptin

CAS: 136033-70-0

Dermaseptin was originally isolated from skin extracts of the South American arboreal frog, Phyllomedusa sauvagei. The strongly basic, nonhemolytic compound is the first vertebrate peptide that shows highly potent antimicrobial activity against pathogenic fungi at micromolar concentration. With a potentially amphiphatic α-helix structure, dermaseptin probably acts by membrane permeabilization.

Formula: C₁₅₂H₂₅₇N₄₃O₄₄S₂

Purity: 99.8%

Color and Shape: White Powder

Molecular weight: 3455.11

Ref: 01-4018008

Dermaseptin-S1

CAS: 136033-70-0

Dermaseptin-S1, an antimicrobial peptide sourced from frog skin, exhibits efficacy against filamentous fungi [1].

Formula: C₁₅₂H₂₅₇N₄₃O₄₄S₂

Color and Shape: Solid

Molecular weight: 3455.06

Ref: TM-T80315

Dermaseptin S trifluoroacetate

CAS: 136033-70-0

Dermaseptin is a cytosolic Ca2+-mobilizing peptide that has antimicrobial activity against oral pathogens. It binds to the intracellular targets (e.g., receptor molecule) and causes cell lysis. Dermaseptin has been shown to have a phase transition temperature of 43°C and is active at concentrations below 0.1μM. Titration calorimetry experiments show that dermaseptin has conformational properties that are similar to those of a linear peptide, but with an amphipathic character. Dermaseptin also interacts with mitochondrial membrane potential and releases cytochrome c from mitochondria into the cytosol, which leads to cell death by apoptosis or necrosis.

Formula: C₁₅₂H₂₅₇N₄₃O₄₄S₂•(C₂HF₃O₂)x

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 3,455.06 g/mol

Ref: 3D-FD73351