CAS 136054-22-3

H-His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2

Description:

The chemical substance with the name "H-His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2" and CAS number "136054-22-3" is a synthetic peptide that consists of a sequence of amino acids, including histidine (His), tryptophan (Trp), lysine (Lys), and phenylalanine (Phe), with specific stereochemistry indicated by the use of D- and L- designations. This peptide is characterized by its potential biological activity, which may include roles in signaling pathways or interactions with receptors. The presence of multiple lysine residues suggests a possibility for positive charge at physiological pH, which can influence its solubility and interaction with other biomolecules. The C-terminal amide group (NH2) can enhance stability and bioactivity. Peptides like this one are often studied for their therapeutic potential, including applications in drug design and development, particularly in areas such as cancer treatment or neurobiology. The specific properties, such as solubility, stability, and biological activity, would depend on the peptide's sequence and structure, as well as the conditions under which it is studied.

Formula: C₄₉H₆₃N₁₃O₆

Synonyms:

• [D-Trp7, D-Lys8, D-Phe10]-Alpha-Melanocyte Stimulating Hormone (6-11) Amide
• (D-Trp7,D-Lys8,D-Phe10)-Alpha-Msh (6-11) Amide
• [D-Lys3]-Ghrp-6
• [D-Lys3]-Ghrp-6 [His1, D-Lys3, Lys6]-Ghrp His-D-Trp-D-Lys-Trp-D-Phe-Lys-Nh2
• [D-Lys3]-Growth Hormone Releasing Peptide
• (D-Lys3)-Growth Hormone-Releasing Peptide-6
• Hwkwfk-Nh2
• [His1, D-Lys3, Lys6]-Ghrp
• M.W. 930.12 C49H63N13O6
• HIS-D-TRP-D-LYS-TRP-D-PHE-LYS-NH2
• (D-Lys3)-GHRP-6 H-His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2
• L-Lysinamide, L-histidyl-D-tryptophyl-D-lysyl-L-tryptophyl-D-phenylalanyl-
• (D-Trp7,D-Lys8,D-Phe10)-α-MSH (6-11) aMide
• L-Histidyl-D-tryptophyl-D-lysyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
• [His1, D-Lys3, Lys6]-GHRP, His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2, [D-Lys3]-Growth Hormone Releasing Peptide 6
• H-HIS-D-TRP-D-LYS-TRP-D-PHE-LYS-NH2
• CHRP-6
• (D-Trp7,D-Lys8,D-Phe10)-a-MSH (6-11) aMide

(D-Lys³)-GHRP-6

CAS: 136054-22-3

A ghrelin receptor antagonist. Asakawa et al. found that peripherally administered (D-Lys³)-GHRP-6 (HwkWfK-amide) decreased food intake in lean mice, in mice with diet induced obesity, and in ob/ob obese mice, and that repeated administration of this GHS-R antagonist decreased body weight gain and improved glycaemic control in ob/ob obese mice.

Formula: C₄₉H₆₃N₁₃O₆

Purity: 99.0%

Color and Shape: White Powder

Molecular weight: 930.12

Ref: 01-4030692

D-Lys3-GHRP-6

Controlled Product

CAS: 136054-22-3

Applications Different doses of D-Lys3-GHRP-6 were injected into rats to observe their memory and learning skills.
References Beheshti, S., et al.: Neuropeptides, 52, 97 (2015).

Formula: C₄₉H₆₃N₁₃O₆•x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 930.10811402

Ref: TR-L488760

H-His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2

CAS: 136054-22-3

H-His-D-Trp-D-Lys-Trp-D-Phe-Lys-NH2 is an inhibitor of cyclase that blocks the conversion of ATP to cAMP. It has shown to have potential as a biomarker for cancer tissues and can be used in experimental models of cancer. HHDLKPDTDLKYSHN2 also inhibits phosphodiesterase, which is involved in the breakdown of cAMP, and can be used to treat bowel disease.

Formula: C₄₉H₆₃N₁₃O₆

Purity: Min. 95%

Molecular weight: 930.13 g/mol

Ref: 3D-PGH-3656-PI

(D-Lys3)-GHRP-6

CAS: 136054-22-3

D-Lys3-GHRP-6 is a synthetic peptide that has been shown to stimulate cellular proliferation and inhibit apoptosis in cell culture. D-Lys3-GHRP-6 binds to the ghrelin receptor, which is found on cells in the stomach and pancreas, as well as in the brain. This binding stimulates the release of cytosolic calcium and enhances protein synthesis. D-Lys3-GHRP-6 also stimulates growth factor production and increases body fat mass in animals.

Formula: C₄₉H₆₃N₁₃O₆

Purity: Min. 95%

Molecular weight: 930.11 g/mol

Ref: 3D-FL108884