CAS 136087-85-9: Fidarestat

Description: Fidarestat, with the CAS number 136087-85-9, is a chemical compound primarily recognized for its role as an aldose reductase inhibitor. This mechanism of action is significant in the context of diabetic complications, as it helps to reduce the conversion of glucose to sorbitol, thereby potentially mitigating osmotic and oxidative stress in tissues. Fidarestat is characterized by its ability to selectively inhibit the enzyme aldose reductase, which is involved in the polyol pathway. The compound is typically studied for its therapeutic potential in managing diabetic neuropathy and retinopathy. In terms of its physical properties, fidarestat is a small organic molecule, and its solubility and stability can vary based on the formulation and conditions. As with many pharmacological agents, its efficacy and safety profile are evaluated through clinical trials, and it may exhibit side effects typical of its class. Overall, fidarestat represents a targeted approach in the treatment of diabetes-related complications, highlighting the importance of enzyme inhibition in pharmacotherapy.

Formula: C₁₂H₁₀FN₃O₄

InChI: InChI=1S/C12H10FN3O4/c13-5-1-2-7-6(3-5)12(4-8(20-7)9(14)17)10(18)15-11(19)16-12/h1-3,8H,4H2,(H2,14,17)(H2,15,16,18,19)/t8-,12-/m0/s1

InChI key: InChIKey=WAAPEIZFCHNLKK-UFBFGSQYSA-N

SMILES: O=C1NC(=O)C2(N1)C3=CC(F)=CC=C3OC(C(=O)N)C2

Synonyms:

• (2S,4S)-2-Aminoformyl-6-Fluoro-Spiro[Chroman-4,4'-Imidazolidine]-2',5'-Dione
• (2S,4S)-6-Fluoro-2',5'-Dioxo-2,3-Dihydrospiro[Chromene-4,4'-Imidazolidine]-2-Carboxamide
• (2S,4S)-6-Fluoro-2',5'-Dioxospiro(3,4-Dihydro-2H-1-Benzopyran-4,4'-Imidazolidine)-2-Carboxamide
• (2S,4S)-6-Fluoro-2,3-dihydro-2′,5′-dioxospiro[4H-1-benzopyran-4,4′-imidazolidine]-2-carboxamide
• Aldos
• Sk 860
• Snk 860
• Spiro[4H-1-benzopyran-4,4′-imidazolidine]-2-carboxamide, 6-fluoro-2,3-dihydro-2′,5′-dioxo-, (2S,4S)-
• Spiro[4H-1-benzopyran-4,4′-imidazolidine]-2-carboxamide, 6-fluoro-2,3-dihydro-2′,5′-dioxo-, (2S-cis)-
• Fidarestat

Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide,6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S,4S)-

CAS: 136087-85-9

• Formula: C₁₂H₁₀FN₃O₄
• Purity: 99.35%
• Molecular weight: 279.22390319999994

Fidarestat

CAS: 136087-85-9

Fidarestat (SNK 860)

CAS: 136087-85-9

• Formula: C₁₂H₁₀FN₃O₄
• Molecular weight: 279.23

Fidarestat-d3

CAS: 136087-85-9

• Formula: C₁₂H₇D₃FN₃O₄
• Molecular weight: 282.25

SNK-860

CAS: 136087-85-9

Inhibitor of aldose reductase

• Formula: C₁₂H₁₀FN₃O₄
• Purity: Min. 95%
• Molecular weight: 279.22 g/mol

Fidarestat

CAS: 136087-85-9

Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for …

• Formula: C₁₂H₁₀FN₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 279.22