CAS 136132-77-9

N-T-boc-arg-val-arg-arg 7-amido-4-*methylcoumarin

Description:

N-T-boc-arg-val-arg-arg 7-amido-4-methylcoumarin is a synthetic compound that belongs to the class of peptide derivatives, specifically designed for use in biochemical research and applications. The "N-T-boc" designation indicates that the arginine residue is protected with a tert-butyloxycarbonyl (Boc) group, which is commonly used in peptide synthesis to prevent unwanted reactions during the coupling process. The compound features a 7-amido-4-methylcoumarin moiety, which is a fluorescent marker, making it useful in various assays, particularly in studying enzyme activity or peptide interactions. The presence of multiple arginine residues suggests potential applications in enhancing solubility and bioactivity, as arginine is known for its positive charge and ability to interact with negatively charged biomolecules. Overall, this compound is valuable in the fields of biochemistry and molecular biology, particularly in the development of peptide-based probes and therapeutic agents.

Formula: C₃₈H₆₂N₁₄O₈

Synonyms:

• Boc-Arg-Val-Arg-Arg-AMC

Boc-Arg-Val-Arg-Arg-AMC

CAS: 136132-77-9

The fluorogenic substrate Boc-RVRR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 4·10³ M⁻¹s⁻¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Boc-RVRR-AMC is also cleaved by proprotein convertase 4. Stock solutions of Boc-RVRR-AMC are best prepared in DMSO.

Formula: C₃₈H₆₂N₁₄O₈

Purity: 97.9%

Color and Shape: White Lyophilisate

Molecular weight: 843.01

Ref: 01-4018735

Boc-Arg-Val-Arg-Arg-AMC acetate salt

Controlled Product

CAS: 136132-77-9

Boc-Arg-Val-Arg-Arg-AMC acetate salt is a protease inhibitor that belongs to the group of basic proteins. It inhibits the action of serine proteases, which are enzymes that break down proteins in cells. Boc-Arg-Val-Arg-Arg-AMC acetate salt has been shown to inhibit leishmania and tumor cell growth. It also inhibits cancer cell proliferation and metastasis. The inhibition of these cancer cell lines by Boc-Arg-Val-Arg-Arg-AMC acetate salt may be due to its ability to inhibit protein synthesis, which is vital for tumor cell growth. Boc Arg Val Arg Arg AMC acetate salt also induces apoptosis (cell death) in some cancer cells through the activation of caspase 3, a cysteine protease that plays an important role in apoptosis signaling pathways.

Formula: C₃₈H₆₂N₁₄O₈

Purity: Min. 95%

Molecular weight: 842.99 g/mol

Ref: 3D-FB110565