CAS 1361569-10-9

Riociguat Impurity 12

CAS: 1361569-10-9

Formula: C₁₈H₁₃FN₈O

Molecular weight: 376.36

Ref: 4Z-R-080017

6-Amino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one

Controlled Product

CAS: 1361569-10-9

Applications 6-Amino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,9-dihydro-8H-purin-8-one is derived from 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-6-triamine (F595655), which is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension;Also, it is an impurity of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.
References Mittendorf, J., et al.: ChemMedChem, 4, 853 (2009); Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002); Straub, A., et al.: Bioorg. Med. Chem., 10, 3075 (2002);Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);

Formula: C₁₈H₁₃FN₈O

Color and Shape: Neat

Molecular weight: 376.347

Ref: TR-A608710

Riociguat Impurity 15

CAS: 1361569-10-9

Formula: C₁₈H₁₃FN₈O

Molecular weight: 376.4

Ref: ST-EA-CP-R35015