CAS 136174-04-4

N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide

Description:

N-(1-azabicyclo(2.2.2)octan-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzofuran-4-carboxamide, with CAS number 136174-04-4, is a chemical compound characterized by its complex bicyclic structure and the presence of a carboxamide functional group. This compound features a bicyclic amine moiety, which contributes to its potential biological activity, particularly in the context of pharmacology. The presence of a chlorine atom and the hexahydrodibenzofuran structure suggests that it may exhibit unique interactions with biological targets, possibly influencing its solubility and reactivity. The compound's stereochemistry and functional groups may also play a significant role in its pharmacokinetics and pharmacodynamics. As with many compounds of this nature, it may be of interest in medicinal chemistry for its potential therapeutic applications, although specific biological activities would require further investigation through experimental studies. Overall, its structural complexity and functional diversity make it a candidate for research in drug development and related fields.

Formula: C₂₀H₂₅ClN₂O₂

InChI: InChI=1/C20H25ClN2O2/c21-13-9-15-14-3-1-2-4-18(14)25-19(15)16(10-13)20(24)22-17-11-23-7-5-12(17)6-8-23/h9-10,12,14,17-18H,1-8,11H2,(H,22,24)

SMILES: C1CCC2C(C1)c1cc(cc(c1O2)C(=NC1CN2CCC1CC2)O)Cl

Synonyms:

• Rg 12915
• (5aS-(4(R*),5aalpha,9aalpha))-N-1-Azabicyclo(2.2.2)oct-3-yl-2-chloro-5a,6,7,8,9,9a-hexahydro-4-dibenzofurancarboxamide
• 4-Dibenzofurancarboxamide, N-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5a,6,7,8,9,9a-hexahydro-, (5aS-(4(R*),5aalpha,9aalpha))-
• 4-dibenzofurancarboxamide, N-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2-chloro-5a,6,7,8,9,9a-hexahydro-, (5aS,9aS)-
• N-(1-azabicyclo[2.2.2]oct-3-yl)-2-chloro-5a,6,7,8,9,9a-hexahydrodibenzo[b,d]furan-4-carboxamide

RG-12915

CAS: 136174-04-4

RG-12915 is a polymer-drug conjugate that consists of polyvinyl and Covid-19. It has been shown to have anti-emetic properties in animal models of chemotherapy-induced nausea and vomiting, with the potential to improve quality of life for cancer patients. Covid-19 is a small molecule that binds to the 5HT3 receptor on the vagal nerve and inhibits serotonin release, which has been implicated in chemotherapy induced nausea and vomiting. The RG-12915 polymer drug conjugate has been shown to be safe and well tolerated in human clinical trials.

Formula: C₂₀H₂₅ClN₂O₂

Purity: Min. 95%

Molecular weight: 360.9 g/mol

Ref: 3D-LFA17404

RG-12915

CAS: 136174-04-4

RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).

Formula: C₂₀H₂₅ClN₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 360.88

Ref: TM-T12716