CAS 136247-07-9
:5-methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)- 2-Naphthalenamine (Rotigotine)
Description:
5-Methoxy-1,2,3,4-tetrahydro-N-(phenylmethyl)-2-naphthalenamine, commonly known as Rotigotine, is a synthetic compound primarily used in the treatment of Parkinson's disease and restless legs syndrome. It acts as a dopamine agonist, mimicking the effects of dopamine in the brain, which is crucial for motor control. The chemical structure features a naphthalene ring system, which contributes to its lipophilicity, allowing for effective penetration of the blood-brain barrier. Rotigotine is typically administered via a transdermal patch, providing a steady release of the drug and minimizing fluctuations in plasma levels. Its pharmacokinetics are characterized by a relatively long half-life, which supports once-daily dosing. The compound exhibits a favorable safety profile, although side effects may include nausea, dizziness, and somnolence. As a member of the naphthylamine class, Rotigotine's unique structure and mechanism of action make it a valuable therapeutic option in managing dopamine-related disorders.
Formula:C18H21NO
InChI:InChI=1/C18H21NO/c1-20-18-9-5-8-15-12-16(10-11-17(15)18)19-13-14-6-3-2-4-7-14/h2-9,16,19H,10-13H2,1H3
SMILES:COc1cccc2CC(CCc12)NCc1ccccc1
Synonyms:- 2-naphthalenamine, 1,2,3,4-tetrahydro-5-methoxy-N-(phenylmethyl)-
- N-Benzyl-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
Sort by
The purity filter is not visible because current products do not have associated purity data for filtering.
Found 2 products.
