CAS 1363380-51-1

5-chloro-3-nitropyrazolo[1,5-a]pyrimidine

Description:

5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine is a heterocyclic compound characterized by its pyrazolo and pyrimidine ring systems, which contribute to its unique chemical properties. The presence of chlorine and nitro functional groups introduces significant reactivity and polarity, making it a potential candidate for various chemical reactions, including nucleophilic substitutions and electrophilic aromatic substitutions. This compound is typically solid at room temperature and may exhibit moderate solubility in polar organic solvents. Its structure suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, due to the biological activity often associated with nitro and chloro-substituted heterocycles. Additionally, the compound's stability under standard laboratory conditions allows for its use in synthetic pathways. However, handling precautions should be observed due to the potential toxicity of nitro compounds. Overall, 5-chloro-3-nitropyrazolo[1,5-a]pyrimidine is a compound of interest in both research and industrial applications, particularly in the fields of organic synthesis and drug development.

Pyrazolo[1,5-a]pyrimidine, 5-chloro-3-nitro-

CAS: 1363380-51-1

Formula: C₆H₃ClN₄O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 198.5666

Ref: IN-DA0011NW

5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine

CAS: 1363380-51-1

5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine

Purity: 97%

Color and Shape: Solid

Molecular weight: 198.57g/mol

Ref: 54-OR52568

5-CHLORO-3-NITROPYRAZOLO[1,5-A]PYRIMIDINE

CAS: 1363380-51-1

Formula: C₆H₃ClN₄O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 198.57

Ref: 10-F467864

5-Chloro-3-nitro-pyrazolo[1,5-a]pyrimidine

Controlled Product

CAS: 1363380-51-1

Applications 5-Chloro-3-nitro-pyrazolo[1,5-a]pyrimidine is used in the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, a tyrosine kinase (TRK) inhibitor for treating cancer.
References Reynolds, M., et al.: PCT Int. Appl. (2017), WO 2017201241 A1 20171123

Formula: C₆H₃ClN₄O₂

Color and Shape: Neat

Molecular weight: 198.57

Ref: TR-C371555

Larotrectinib Impurity 9

CAS: 1363380-51-1

Formula: C₆H₃ClN₄O₂

Molecular weight: 198.57

Ref: ST-EA-CP-L80007

5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine

CAS: 1363380-51-1

Larotrectinib is a drug used to treat a type of cancer called TRK fusion cancers. This drug has been shown to be effective in vitro and in vivo by inhibiting the growth of tumour cells with mutant TRK fusions. Larotrectinib binds competitively to the ATP-binding site of the TRK receptor, blocking its activation by ATP. Larotrectinib has been shown to inhibit the proliferation of cells with mutant TRK fusions in culture and in animal models, including a mouse model for human breast cancer.

Formula: C₆H₃ClN₄O₂

Purity: Min. 95%

Molecular weight: 198.57 g/mol

Ref: 3D-FC164744