CAS 136470-78-5

Abacavir

Description:

Abacavir is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). The chemical formula of abacavir is C14H18N6O, and it features a bicyclic structure that includes a purine-like moiety. Abacavir is known for its ability to inhibit the reverse transcriptase enzyme, which is crucial for the replication of the HIV virus. One of its notable characteristics is its potential for hypersensitivity reactions, which can be severe and are often associated with specific genetic markers, such as HLA-B*5701. This necessitates genetic screening before initiation of therapy. Abacavir is typically administered orally and is well-absorbed in the gastrointestinal tract. It has a relatively long half-life, allowing for once or twice-daily dosing. Additionally, it is often used in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance development. Overall, abacavir plays a significant role in modern HIV treatment regimens.

Formula: C₁₄H₁₈N₆O

InChI: InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1

InChI key: InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N

SMILES: N(C1=C2C(N(C=N2)[C@@H]3C[C@H](CO)C=C3)=NC(N)=N1)C4CC4

Synonyms:

• (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
• 1592U89
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-
• 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S-cis)-
• 2-Cyclopentene-1-methanol,4-[2-a-mino-6-(cyclopropylamino)-9H-purin-9-yl]-,(1S,4R)
• ABC
• {(1R,4S)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
• {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
• {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol sulfate (2:1)
• Abacavir

Abacavir

CAS: 136470-78-5

Formula: C₁₄H₁₈N₆O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 286.34

Ref: 3B-A2694

2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-

CAS: 136470-78-5

Formula: C₁₄H₁₈N₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 286.3323

Ref: IN-DA0011WC

Abacavir

CAS: 136470-78-5

Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine.

Formula: C₁₄H₁₈N₆O

Purity: 99.36% - 99.81%

Color and Shape: White Powder

Molecular weight: 286.33

Ref: TM-T1267

Abacavir Sulfate

CAS: 136470-78-5

Formula: C₁₄H₁₈N₆O·H₂SO₄

Color and Shape: White To Off-White Solid

Molecular weight: 2*286.34 98.08

Ref: 4Z-A-281

Abacavir

CAS: 136470-78-5

Abacavir

Purity: ≥98%

Molecular weight: 286.33g/mol

Ref: 54-BUP15638

((1S,4R)-4-(2-Amino-6-(Cyclopropylamino)-9H-Purin-9-yl)Cyclopent-2-en-1-yl)Methanol

CAS: 136470-78-5

((1S,4R)-4-(2-Amino-6-(Cyclopropylamino)-9H-Purin-9-yl)Cyclopent-2-en-1-yl)Methanol

Purity: 98%

Molecular weight: 286.33g/mol

Ref: 54-OR1007766

Abacavir

CAS: 136470-78-5

Formula: C₁₄H₁₈N₆O

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 286.33

Ref: 7W-GP1173

Abacavir Impurity 2

CAS: 136470-78-5

Formula: C₁₀H₁₄ClN₅O

Color and Shape: White To Off-White Solid

Molecular weight: 255.71

Ref: 4Z-A-2811

Abacavir (1.0 mg/mL in Methanol)

CAS: 136470-78-5

Formula: C₁₄H₁₈N₆O

Color and Shape: Colourless

Molecular weight: 286.33

Ref: TR-KIT7770

N-Nitroso Abacavir

Controlled Product

CAS: 136470-78-5

Formula: C₁₄H₁₇N₇O₂

Color and Shape: Light Yellow To Yellow

Molecular weight: 315.33

Ref: TR-A105070

Abacavir

Controlled Product

CAS: 136470-78-5

Impurity Abacavir API
Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₁₄H₁₈N₆O

Color and Shape: Off White

Molecular weight: 286.33

Ref: TR-A104990

Abacavir

CAS: 136470-78-5

Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase (RT) inhibitor with anti-retroviral activity against HIV. Good oral bioavailability, high aqueous solubility and good cerebrospinal fluid penetrance. Synergistic with other nucleoside RT inhibitors such as AZT.

Formula: C₁₄H₁₈N₆O

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 286.33 g/mol

Ref: 3D-NA10018

Abacavir

CAS: 136470-78-5

Formula: C₁₄H₁₈N₆O

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 286.339

Ref: 10-F463835

Abacavir - Bio-X ™

CAS: 136470-78-5

Abacavir is an antiviral nucleoside reverse transcriptase inhibitor that is used for the treatment of HIV. This drug inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with dGTP and by its incorporation into viral DNA.

Formula: C₁₄H₁₈N₆O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 286.33 g/mol

Ref: 3D-BA166801