CAS 136470-78-5: Abacavir

Description:Abacavir is an antiretroviral medication primarily used in the treatment of HIV infection. It belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). The chemical formula of abacavir is C14H18N6O, and it features a bicyclic structure that includes a purine-like moiety. Abacavir is known for its ability to inhibit the reverse transcriptase enzyme, which is crucial for the replication of the HIV virus. One of its notable characteristics is its potential for hypersensitivity reactions, which can be severe and are often associated with specific genetic markers, such as HLA-B*5701. This necessitates genetic screening before initiation of therapy. Abacavir is typically administered orally and is well-absorbed in the gastrointestinal tract. It has a relatively long half-life, allowing for once or twice-daily dosing. Additionally, it is often used in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance development. Overall, abacavir plays a significant role in modern HIV treatment regimens.

Formula:C₁₄H₁₈N₆O

InChI:InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1

InChI key:InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N

SMILES:OCC1C=CC(N2C=NC=3C(=NC(=NC32)N)NC4CC4)C1

Synonyms:
(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
1592U89
2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-
2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S-cis)-
2-Cyclopentene-1-methanol,4-[2-a-mino-6-(cyclopropylamino)-9H-purin-9-yl]-,(1S,4R)
ABC
{(1R,4S)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol sulfate (2:1)
Abacavir
See more synonyms

Found 14 products.

Product data	Purity	Price range	Estimated delivery
Abacavir REF: 3B-A2694CAS: 136470-78-5	>98.0%(T)(HPLC)	91.00 €~299.00 €	Tue 29 Apr 25
2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)- REF: IN-DA0011WCCAS: 136470-78-5	98%	To inquire	Tue 06 May 25
Abacavir REF: TM-T1267CAS: 136470-78-5	99.36% - 99.81%	35.00 €~344.00 €	Tue 06 May 25
Abacavir Sulfate REF: 4Z-A-281CAS: 136470-78-5	- - -	To inquire	Mon 05 May 25
Abacavir REF: 54-BUP15638CAS: 136470-78-5	≥98%	149.00 €~515.00 €	Mon 05 May 25
((1S,4R)-4-(2-Amino-6-(Cyclopropylamino)-9H-Purin-9-yl)Cyclopent-2-en-1-yl)Methanol REF: 54-OR1007766CAS: 136470-78-5	98%	32.00 €~1,896.00 €	Mon 05 May 25
Abacavir REF: 7W-GP1173CAS: 136470-78-5	≥ 98.0% (dried basis)	79.00 €~243.00 €	Mon 05 May 25
Abacavir Impurity 2 REF: 4Z-A-2811CAS: 136470-78-5	- - -	To inquire	Tue 13 May 25
N-Nitroso Abacavir REF: TR-A105070CAS: 136470-78-5	- - -	319.00 €~5,339.00 €	Wed 14 May 25
Abacavir REF: 10-F463835CAS: 136470-78-5	95.0%	To inquire	Wed 14 May 25
Abacavir REF: TR-A104990CAS: 136470-78-5	- - -	156.00 €~280.00 €	Wed 14 May 25
Abacavir (1.0 mg/mL in Methanol) REF: TR-KIT7770CAS: 136470-78-5	- - -	1,156.00 €	Wed 14 May 25
Abacavir REF: 3D-NA10018CAS: 136470-78-5	Min. 98 Area-%	143.00 €~1,326.00 €	Thu 15 May 25
Abacavir - Bio-X ™ REF: 3D-BA166801CAS: 136470-78-5	Min. 95%	147.00 €	Thu 15 May 25